Sensors 2013, 13(5), 6217-6228; doi:10.3390/s130506217
Review

Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds

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Received: 22 March 2013; in revised form: 28 April 2013 / Accepted: 2 May 2013 / Published: 13 May 2013
(This article belongs to the Section Biosensors)
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Abstract: Quorum sensing is a system of stimuli and responses in relation to bacterial cell population density that regulates gene expression, including virulence determinants. Consequently, quorum sensing has been an attractive target for the development of novel anti-infective measures that do not rely on the use of antibiotics. Anti-quorum sensing has been a promising strategy to combat bacterial infections as it is unlikely to develop multidrug resistant pathogens since it does not impose any selection pressure. A number of anti-quorum sensing approaches have been documented and plant-based natural products have been extensively studied in this context. Plant matter is one of the major sources of chemicals in use today in various industries, ranging from the pharmaceutical, cosmetic, and food biotechnology to the textile industries. Just like animals and humans, plants are constantly exposed to bacterial infections, it is therefore logical to expect that plants have developed sophisticated of chemical mechanisms to combat pathogens. In this review, we have surveyed the various types of plant-based natural products that exhibit anti-quorum sensing properties and their anti-quorum sensing mechanisms.
Keywords: anti-infective; autoinducer; bacterial cell-to-cell communication; biofilm; infectious diseases; N-acylhomoserine lactones; pathogen; quorum quenching; quorum sensing; virulence factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Koh, C.-L.; Sam, C.-K.; Yin, W.-F.; Tan, L.Y.; Krishnan, T.; Chong, Y.M.; Chan, K.-G. Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds. Sensors 2013, 13, 6217-6228.

AMA Style

Koh C-L, Sam C-K, Yin W-F, Tan LY, Krishnan T, Chong YM, Chan K-G. Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds. Sensors. 2013; 13(5):6217-6228.

Chicago/Turabian Style

Koh, Chong-Lek; Sam, Choon-Kook; Yin, Wai-Fong; Tan, Li Y.; Krishnan, Thiba; Chong, Yee M.; Chan, Kok-Gan. 2013. "Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds." Sensors 13, no. 5: 6217-6228.


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