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Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds
Natural Sciences and Science Education AG, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, 637616, Singapore
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
* Author to whom correspondence should be addressed.
Received: 22 March 2013; in revised form: 28 April 2013 / Accepted: 2 May 2013 / Published: 13 May 2013
Abstract: Quorum sensing is a system of stimuli and responses in relation to bacterial cell population density that regulates gene expression, including virulence determinants. Consequently, quorum sensing has been an attractive target for the development of novel anti-infective measures that do not rely on the use of antibiotics. Anti-quorum sensing has been a promising strategy to combat bacterial infections as it is unlikely to develop multidrug resistant pathogens since it does not impose any selection pressure. A number of anti-quorum sensing approaches have been documented and plant-based natural products have been extensively studied in this context. Plant matter is one of the major sources of chemicals in use today in various industries, ranging from the pharmaceutical, cosmetic, and food biotechnology to the textile industries. Just like animals and humans, plants are constantly exposed to bacterial infections, it is therefore logical to expect that plants have developed sophisticated of chemical mechanisms to combat pathogens. In this review, we have surveyed the various types of plant-based natural products that exhibit anti-quorum sensing properties and their anti-quorum sensing mechanisms.
Keywords: anti-infective; autoinducer; bacterial cell-to-cell communication; biofilm; infectious diseases; N-acylhomoserine lactones; pathogen; quorum quenching; quorum sensing; virulence factors
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Koh, C.-L.; Sam, C.-K.; Yin, W.-F.; Tan, L.Y.; Krishnan, T.; Chong, Y.M.; Chan, K.-G. Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds. Sensors 2013, 13, 6217-6228.
Koh C-L, Sam C-K, Yin W-F, Tan LY, Krishnan T, Chong YM, Chan K-G. Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds. Sensors. 2013; 13(5):6217-6228.
Koh, Chong-Lek; Sam, Choon-Kook; Yin, Wai-Fong; Tan, Li Y.; Krishnan, Thiba; Chong, Yee M.; Chan, Kok-Gan. 2013. "Plant-Derived Natural Products as Sources of Anti-Quorum Sensing Compounds." Sensors 13, no. 5: 6217-6228.