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Sensors 2013, 13(5), 5937-5944; doi:10.3390/s130505937

DNA Hairpins as Temperature Switches, Thermometers and Ionic Detectors

Laboratory of Genome Research, Department of Molecular Biology and Genetics, Aarhus University, C.F. Moellers Allè 3, Building 1130, 8000 Aarhus C, Denmark
Author to whom correspondence should be addressed.
Received: 28 March 2013 / Revised: 25 April 2013 / Accepted: 5 May 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Fluorescent Biosensors)
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Temperature is of major importance in most branches of science and technology as well as in everyday life, and with the miniaturization of electronic devices and the increasing ability to make research into small-scale systems, a specific need for very small thermostats and thermometers has been created. Here we describe how DNA molecules can be used as nanoscale sensors to meet these requirements. We illustrate how the hybridization kinetics between bases in DNA molecules combined with conformational changes of the DNA backbone can be exploited in the construction of simple but versatile temperature switches and thermometers, which can be built into electronic systems. DNA based sensors are at the same time applicable as ion detectors to monitor the chemical environment of a specific system. View Full-Text
Keywords: temperature sensing; DNA hairpin; fluorescence readout; temperature switch; ionic detector temperature sensing; DNA hairpin; fluorescence readout; temperature switch; ionic detector

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jonstrup, A.T.; Fredsøe, J.; Andersen, A.H. DNA Hairpins as Temperature Switches, Thermometers and Ionic Detectors. Sensors 2013, 13, 5937-5944.

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