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Sensors 2013, 13(3), 3169-3203; doi:10.3390/s130303169
Review

Opening up the Window into “Chemobrain”: A Neuroimaging Review

1,*  and 2
Received: 1 January 2013; in revised form: 5 February 2013 / Accepted: 16 February 2013 / Published: 6 March 2013
(This article belongs to the Special Issue Medical & Biological Imaging)
View Full-Text   |   Download PDF [278 KB, updated 21 June 2014; original version uploaded 21 June 2014]
Abstract: As more chemotherapy-treated cancer patients are reaching survivorship, side-effects such as cognitive impairment warrant research attention. The advent of neuroimaging has helped uncover a neural basis for these deficits. This paper offers a review of neuroimaging investigations in chemotherapy-treated adult cancer patients, discussing the benefits and limitations of each technique and study design. Additionally, despite the assumption given by the chemobrain label that chemotherapy is the only causative agent of these deficits, other factors will be considered. Suggestions are made on how to more comprehensively study these cognitive changes using imaging techniques, thereby promoting generalizability of the results to clinical applications. Continued investigations may yield better long-term quality of life outcomes by supporting patients’ self-reports, and revealing brain regions being affected by chemotherapy.
Keywords: chemotherapy; cognitive impairment; chemobrain; neuroimaging; cancer survivorship issues chemotherapy; cognitive impairment; chemobrain; neuroimaging; cancer survivorship issues
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Scherling, C.S.; Smith, A. Opening up the Window into “Chemobrain”: A Neuroimaging Review. Sensors 2013, 13, 3169-3203.

AMA Style

Scherling CS, Smith A. Opening up the Window into “Chemobrain”: A Neuroimaging Review. Sensors. 2013; 13(3):3169-3203.

Chicago/Turabian Style

Scherling, Carole S.; Smith, Andra. 2013. "Opening up the Window into “Chemobrain”: A Neuroimaging Review." Sensors 13, no. 3: 3169-3203.


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