Next Article in Journal
Combining Wireless Sensor Networks and Semantic Middleware for an Internet of Things-Based Sportsman/Woman Monitoring Application
Next Article in Special Issue
Rapid and Highly Sensitive Detection of Lead Ions in Drinking Water Based on a Strip Immunosensor
Previous Article in Journal
Enhancement of NH3 Gas Sensitivity at Room Temperature by Carbon Nanotube-Based Sensor Coated with Co Nanoparticles
Previous Article in Special Issue
Measurement of Urinary N-Telopeptides and Serum C-Telopeptides from Type I Collagen Using a Lateral Flow-Based Immunoassay
Sensors 2013, 13(2), 1763-1786; doi:10.3390/s130201763

Recent Advances in Bacteriophage Based Biosensors for Food-Borne Pathogen Detection

1,2,* , 1,2
1 Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB T6G 2V4, Canada 2 National Institute for Nanotechnology, University of Alberta, Edmonton, AB T6G 2M9, Canada
* Author to whom correspondence should be addressed.
Received: 17 November 2012 / Revised: 16 January 2013 / Accepted: 29 January 2013 / Published: 30 January 2013
View Full-Text   |   Download PDF [604 KB, 21 June 2014; original version 21 June 2014]   |   Browse Figures


Foodborne diseases are a major health concern that can have severe impact on society and can add tremendous financial burden to our health care systems. Rapid early detection of food contamination is therefore relevant for the containment of food-borne pathogens. Conventional pathogen detection methods, such as microbiological and biochemical identification are time-consuming and laborious, while immunological or nucleic acid-based techniques require extensive sample preparation and are not amenable to miniaturization for on-site detection. Biosensors have shown tremendous promise to overcome these limitations and are being aggressively studied to provide rapid, reliable and sensitive detection platforms for such applications. Novel biological recognition elements are studied to improve the selectivity and facilitate integration on the transduction platform for sensitive detection. Bacteriophages are one such unique biological entity that show excellent host selectivity and have been actively used as recognition probes for pathogen detection. This review summarizes the extensive literature search on the application of bacteriophages (and recently their receptor binding proteins) as probes for sensitive and selective detection of foodborne pathogens, and critically outlines their advantages and disadvantages over other recognition elements.
Keywords: bacteriophage; biological probes; biosensors; food-borne pathogens; signal transduction; pathogens bacteriophage; biological probes; biosensors; food-borne pathogens; signal transduction; pathogens
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Singh, A.; Poshtiban, S.; Evoy, S. Recent Advances in Bacteriophage Based Biosensors for Food-Borne Pathogen Detection. Sensors 2013, 13, 1763-1786.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert