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Sensors 2013, 13(1), 152-164; doi:10.3390/s130100152
Article

Detectability of Absorption and Reduced Scattering Coefficients in Frequency-Domain Measurements Using a Realistic Head Phantom

1,*  and 2
Received: 7 November 2012; in revised form: 17 December 2012 / Accepted: 18 December 2012 / Published: 24 December 2012
(This article belongs to the Special Issue Medical & Biological Imaging)
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Abstract: Detection limits of the changes in absorption and reduced scattering coefficients were investigated using a frequency-domain near-infrared system in a realistic head phantom. The results were quantified in terms of the maximum detectable depth for different activation volumes in the range of 0.8–20 microliters. The non-linear relation between the maximum detectable depth and the magnitude of changes in the absorption coefficient conform well with the Born approximation to the diffusion equation. The minimal detectable changes in the reduced scattering coefficient measured in terms of the phase signal were found to be approximately twice as large as that of the absorption coefficient using the AC signal for the same volume and at the same depth. The phase delay, which can be used to quantify the fast neuronal optical response in the human brain, showed a linear dependence on the reciprocal of the reduced scattering coefficient, as predicted by the Rytov approximation.
Keywords: near infrared; absorption; scattering; fast signal; detectability; sensitivity; frequency domain; phantom; human head near infrared; absorption; scattering; fast signal; detectability; sensitivity; frequency domain; phantom; human head
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, X.; Webb, A. Detectability of Absorption and Reduced Scattering Coefficients in Frequency-Domain Measurements Using a Realistic Head Phantom. Sensors 2013, 13, 152-164.

AMA Style

Zhang X, Webb A. Detectability of Absorption and Reduced Scattering Coefficients in Frequency-Domain Measurements Using a Realistic Head Phantom. Sensors. 2013; 13(1):152-164.

Chicago/Turabian Style

Zhang, Xiaofeng; Webb, Andrew. 2013. "Detectability of Absorption and Reduced Scattering Coefficients in Frequency-Domain Measurements Using a Realistic Head Phantom." Sensors 13, no. 1: 152-164.



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