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Sensors 2012, 12(5), 6645-6665; doi:10.3390/s120506645
Review

Detection of AI-2 Receptors in Genomes of Enterobacteriaceae Suggests a Role of Type-2 Quorum Sensing in Closed Ecosystems

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 and *
Received: 31 March 2012; in revised form: 11 May 2012 / Accepted: 16 May 2012 / Published: 21 May 2012
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Abstract: The LuxS enzyme, an S-ribosyl-homocysteine lyase, catalyzes the production of the signal precursor for autoinducer-2 mediated quorum sensing (QS-2) in Vibrio. Its widespread occurrence among bacteria is often considered the evidence for a universal language for interspecies communication. Presence of the luxS gene and production of the autoinducer-2 (AI-2) signal have repeatedly been the only evidences presented to assign a functional QS-2 to the most diverse species. In fact, LuxS has a primary metabolic role as part of the activated methyl cycle. In this review we have analyzed the distribution of QS-2 related genes in Enterobacteriaceae by moving the focus of the investigation from AI-2 production to the detection of potential AI-2 receptors. The latter are common in pathogens or endosymbionts of animals, but were also found in a limited number of Enterobacteriaceae of the genera Enterobacter, Klebsiella, and Pantoea that live in close association with plants or fungi. Although a precise function of QS-2 in these species has not been identified, they all show an endophytic or endosymbiontic lifestyle that suggests a role of type-2 quorum sensing in the adaptation to closed ecosystems.
Keywords: LuxS; N-acyl homoserine lactone; Erwinia; Pantoea; Salmonella; Serratia; Enterobacter; metabolism; autoinducer; plant pathogen; nitrogen fixation LuxS; N-acyl homoserine lactone; Erwinia; Pantoea; Salmonella; Serratia; Enterobacter; metabolism; autoinducer; plant pathogen; nitrogen fixation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rezzonico, F.; Smits, T.H.M.; Duffy, B. Detection of AI-2 Receptors in Genomes of Enterobacteriaceae Suggests a Role of Type-2 Quorum Sensing in Closed Ecosystems. Sensors 2012, 12, 6645-6665.

AMA Style

Rezzonico F, Smits THM, Duffy B. Detection of AI-2 Receptors in Genomes of Enterobacteriaceae Suggests a Role of Type-2 Quorum Sensing in Closed Ecosystems. Sensors. 2012; 12(5):6645-6665.

Chicago/Turabian Style

Rezzonico, Fabio; Smits, Theo H. M.; Duffy, Brion. 2012. "Detection of AI-2 Receptors in Genomes of Enterobacteriaceae Suggests a Role of Type-2 Quorum Sensing in Closed Ecosystems." Sensors 12, no. 5: 6645-6665.


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