Sensors 2012, 12(4), 5159-5169; doi:10.3390/s120405159
Review

HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification

Adam J. Kimple 1 email, Alexandra D. Torres 2,3 email, Robert Z. Yang 2,3 email and Randall J. Kimple 2,4,* email
1 School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA 2 Department of Human Oncology, University of Wisconsin, Madison, WI 53706, USA 3 McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA 4 Carbone Cancer Center, University of Wisconsin, Madison, WI 53792, USA
* Author to whom correspondence should be addressed.
Received: 1 March 2012; in revised form: 27 March 2012 / Accepted: 18 April 2012 / Published: 20 April 2012
(This article belongs to the Special Issue Biomarkers and Nanosensors: New Approaches for Biology and Medicine)
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Abstract: Over the last 10 years, it has become clear that patients with head and neck cancer can be stratified into two distinct subgroups on the basis of the etiology of their disease. Patients with human papillomavirus-related cancers have significantly better survival rates and may necessitate different therapeutic approaches than those with tobacco and/or alcohol related cancers. This review discusses the various biomarkers currently in use for identification of patients with HPV-positive cancers with a focus on the advantages and limitations of molecular and nano-scale markers.
Keywords: human papillomavirus; head and neck cancer; in situ hybridization; next generation sequencing; biomarkers

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Cite This Article

MDPI and ACS Style

Kimple, A.J.; Torres, A.D.; Yang, R.Z.; Kimple, R.J. HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification. Sensors 2012, 12, 5159-5169.

AMA Style

Kimple AJ, Torres AD, Yang RZ, Kimple RJ. HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification. Sensors. 2012; 12(4):5159-5169.

Chicago/Turabian Style

Kimple, Adam J.; Torres, Alexandra D.; Yang, Robert Z.; Kimple, Randall J. 2012. "HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification." Sensors 12, no. 4: 5159-5169.

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