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Sensors 2012, 12(4), 5159-5169; doi:10.3390/s120405159

HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification

1
School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
2
Department of Human Oncology, University of Wisconsin, Madison, WI 53706, USA
3
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA
4
Carbone Cancer Center, University of Wisconsin, Madison, WI 53792, USA
*
Author to whom correspondence should be addressed.
Received: 1 March 2012 / Revised: 27 March 2012 / Accepted: 18 April 2012 / Published: 20 April 2012
(This article belongs to the Special Issue Biomarkers and Nanosensors: New Approaches for Biology and Medicine)
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Abstract

Over the last 10 years, it has become clear that patients with head and neck cancer can be stratified into two distinct subgroups on the basis of the etiology of their disease. Patients with human papillomavirus-related cancers have significantly better survival rates and may necessitate different therapeutic approaches than those with tobacco and/or alcohol related cancers. This review discusses the various biomarkers currently in use for identification of patients with HPV-positive cancers with a focus on the advantages and limitations of molecular and nano-scale markers.
Keywords: human papillomavirus; head and neck cancer; in situ hybridization; next generation sequencing; biomarkers human papillomavirus; head and neck cancer; in situ hybridization; next generation sequencing; biomarkers
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kimple, A.J.; Torres, A.D.; Yang, R.Z.; Kimple, R.J. HPV-Associated Head and Neck Cancer: Molecular and Nano-Scale Markers for Prognosis and Therapeutic Stratification. Sensors 2012, 12, 5159-5169.

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