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Sensors 2012, 12(4), 5005-5027; doi:10.3390/s120405005
Review
Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications
New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea
†
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 28 February 2012; in revised form: 3 April 2012 / Accepted: 9 April 2012 / Published: 18 April 2012
(This article belongs to the Special Issue Synthetic Fluorescent Indicators for Low Molecular Weight Organic Metabolites)
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Abstract: Glucose homeostasis is a fundamental aspect of life and its dysregulation is associated with important diseases, such as cancer and diabetes. Traditionally, glucose radioisotopes have been used to monitor glucose utilization in biological systems. Fluorescent-tagged glucose analogues were initially developed in the 1980s, but it is only in the past decade that their use as a glucose sensor has increased significantly. These analogues were developed for monitoring glucose uptake in blood cells, but their recent applications include tracking glucose uptake by tumor cells and imaging brain cell metabolism. This review outlines the development of fluorescent-tagged glucose analogues, describes their recent structural modifications and discusses their increasingly diverse biological applications.
Keywords: glucose homeostasis; fluorescent-tagged glucose; bioprobe; bioimaging
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MDPI and ACS Style
Kim, W.H.; Lee, J.; Jung, D.-W.; Williams, D.R. Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications. Sensors 2012, 12, 5005-5027.
AMA StyleKim WH, Lee J, Jung D-W, Williams DR. Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications. Sensors. 2012; 12(4):5005-5027.
Chicago/Turabian StyleKim, Woong Hee; Lee, Jinho; Jung, Da-Woon; Williams, Darren R. 2012. "Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications." Sensors 12, no. 4: 5005-5027.