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Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
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Received: 18 January 2012; in revised form: 14 March 2012 / Accepted: 22 March 2012 / Published: 29 March 2012
Abstract: Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.
Keywords: anti-quorum sensing; bioluminescence; lecA::lux; Malaysian plants; N-acyl-L-homoserine lactones (AHL); Pseudomonas aeruginosa PAO1; pyocyanin; virulence; swarming motility
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Tan, L.Y.; Yin, W.-F.; Chan, K.-G. Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda . Sensors 2012, 12, 4339-4351.
Tan LY, Yin W-F, Chan K-G. Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda . Sensors. 2012; 12(4):4339-4351.
Tan, Li Ying; Yin, Wai-Fong; Chan, Kok-Gan. 2012. "Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda ." Sensors 12, no. 4: 4339-4351.