Sensors 2012, 12(4), 4339-4351; doi:10.3390/s120404339
Article

Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda

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Received: 18 January 2012; in revised form: 14 March 2012 / Accepted: 22 March 2012 / Published: 29 March 2012
(This article belongs to the Section Biosensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.
Keywords: anti-quorum sensing; bioluminescence; lecA::lux; Malaysian plants; N-acyl-L-homoserine lactones (AHL); Pseudomonas aeruginosa PAO1; pyocyanin; virulence; swarming motility
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MDPI and ACS Style

Tan, L.Y.; Yin, W.-F.; Chan, K.-G. Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda . Sensors 2012, 12, 4339-4351.

AMA Style

Tan LY, Yin W-F, Chan K-G. Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda . Sensors. 2012; 12(4):4339-4351.

Chicago/Turabian Style

Tan, Li Ying; Yin, Wai-Fong; Chan, Kok-Gan. 2012. "Silencing Quorum Sensing through Extracts of Melicope lunu-ankenda ." Sensors 12, no. 4: 4339-4351.

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