A Novel In Vitro Sensing Configuration for Retinal Physiology Analysis of a Sub-Retinal Prosthesis
AbstractThis paper presents a novel sensing configuration for retinal physiology analysis, using two microelectrode arrays (MEAs). In order to investigate an optimized stimulation protocol for a sub-retinal prosthesis, retinal photoreceptor cells are stimulated, and the response of retinal ganglion cells is recorded in an in vitro environment. For photoreceptor cell stimulation, a polyimide-substrate MEA is developed, using the microelectromechanical systems (MEMS) technology. For ganglion cell response recording, a conventional glass-substrate MEA is utilized. This new sensing configuration is used to record the response of retinal ganglion cells with respect to three different stimulation methods (monopolar, bipolar, and dual-monopolar stimulation methods). Results show that the geometrical relation between the stimulation microelectrode locations and the response locations seems very low. The threshold charges of the bipolar stimulation and the monopolar stimulation are in the range of 10~20 nC. The threshold charge of the dual-monopolar stimulation is not obvious. These results provide useful guidelines for developing a sub-retinal prosthesis. View Full-Text
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Koo, K.-I.; Lee, S.; Yee, J.H.; Ryu, S.B.; Kim, K.H.; Goo, Y.S.; Cho, D.-I. A Novel In Vitro Sensing Configuration for Retinal Physiology Analysis of a Sub-Retinal Prosthesis. Sensors 2012, 12, 3131-3144.
Koo K-I, Lee S, Yee JH, Ryu SB, Kim KH, Goo YS, Cho D-I. A Novel In Vitro Sensing Configuration for Retinal Physiology Analysis of a Sub-Retinal Prosthesis. Sensors. 2012; 12(3):3131-3144.Chicago/Turabian Style
Koo, Kyo-in; Lee, Sangmin; Yee, Jang Hee; Ryu, Sang Baek; Kim, Kyung Hwan; Goo, Yong Sook; Cho, Dong-il Dan. 2012. "A Novel In Vitro Sensing Configuration for Retinal Physiology Analysis of a Sub-Retinal Prosthesis." Sensors 12, no. 3: 3131-3144.