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Sensors 2012, 12(2), 1657-1687; doi:10.3390/s120201657
Review

Noble Metal Nanoparticles for Biosensing Applications

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1 CIGMH, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal 2 Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Campus Río Ebro, Edifício I+D, Mariano Esquillor, s/n, 50018 Zaragoza, Spain 3 CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal 4 REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal
* Author to whom correspondence should be addressed.
Received: 20 December 2011 / Revised: 29 January 2012 / Accepted: 2 February 2012 / Published: 7 February 2012
(This article belongs to the Special Issue Nano-Biosensors)
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Abstract

In the last decade the use of nanomaterials has been having a great impact in biosensing. In particular, the unique properties of noble metal nanoparticles have allowed for the development of new biosensing platforms with enhanced capabilities in the specific detection of bioanalytes. Noble metal nanoparticles show unique physicochemical properties (such as ease of functionalization via simple chemistry and high surface-to-volume ratios) that allied with their unique spectral and optical properties have prompted the development of a plethora of biosensing platforms. Additionally, they also provide an additional or enhanced layer of application for commonly used techniques, such as fluorescence, infrared and Raman spectroscopy. Herein we review the use of noble metal nanoparticles for biosensing strategies—from synthesis and functionalization to integration in molecular diagnostics platforms, with special focus on those that have made their way into the diagnostics laboratory.
Keywords: nanotechnology; noble metal nanoparticles; biosensors; molecular diagnostics; immunoassays; DNA; RNA; nucleic acids; proteins; antibody nanotechnology; noble metal nanoparticles; biosensors; molecular diagnostics; immunoassays; DNA; RNA; nucleic acids; proteins; antibody
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Doria, G.; Conde, J.; Veigas, B.; Giestas, L.; Almeida, C.; Assunção, M.; Rosa, J.; Baptista, P.V. Noble Metal Nanoparticles for Biosensing Applications. Sensors 2012, 12, 1657-1687.

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