Sensors 2012, 12(10), 13471-13479; doi:10.3390/s121013471
Article

A Novel CD105 Determination System Based on an Ultrasensitive Bioelectrochemical Strategy with Pt Nanoparticles

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Received: 8 August 2012; in revised form: 7 September 2012 / Accepted: 20 September 2012 / Published: 8 October 2012
(This article belongs to the Special Issue Bioassays)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: CD105 is a well-known tumor metastasis marker and useful for early monitoring of metastasis and cancer relapse. It is important to generate rapid, reliable and precise analytical information regarding CD105 levels. To establish a simple, selective and sensitive detection method, we prepared an immunosensor with novel bioconjugates based on Pt nanoparticles, thionin acetate and antibodies. The proposed immunosensor displayed a broader linear response to CD105, with a working range of 1.3 to 200.0 ng/mL and a detection limit of 0.9 ng/mL under optimal conditions. Moreover, the studied immunosensor exhibited high sensitivity, fast analysis and adequate stability. The proposed methodology could readily be extended to other clinical- or environment-related biospecies.
Keywords: CD105; immunosensor; nanomaterial
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MDPI and ACS Style

Zeng, S.; Wang, S.; Wang, L.; Yang, L.; Chen, Z.; Liang, Z. A Novel CD105 Determination System Based on an Ultrasensitive Bioelectrochemical Strategy with Pt Nanoparticles. Sensors 2012, 12, 13471-13479.

AMA Style

Zeng S, Wang S, Wang L, Yang L, Chen Z, Liang Z. A Novel CD105 Determination System Based on an Ultrasensitive Bioelectrochemical Strategy with Pt Nanoparticles. Sensors. 2012; 12(10):13471-13479.

Chicago/Turabian Style

Zeng, Suyun; Wang, Sujun; Wang, Li; Yang, Lihua; Chen, Zhenbo; Liang, Zhiqing. 2012. "A Novel CD105 Determination System Based on an Ultrasensitive Bioelectrochemical Strategy with Pt Nanoparticles." Sensors 12, no. 10: 13471-13479.


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