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Sensors 2011, 11(3), 2796-2808; doi:10.3390/s110302796

Characteristics of Polysilicon Wire Glucose Sensors with a Surface Modified by Silica Nanoparticles/γ-APTES Nanocomposite

1
Department of Applied Materials and Optoelectronic Engineering, National Chi Nan University, Puli, Nantou 54561, Taiwan
2
Department of Electrical Engineering, National Chi Nan University, Puli, Nantou 54561, Taiwan
*
Author to whom correspondence should be addressed.
Received: 28 January 2011 / Revised: 14 February 2011 / Accepted: 28 February 2011 / Published: 2 March 2011
(This article belongs to the Section Biosensors)
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Abstract

This report investigates the sensing characteristics of polysilicon wire (PSW) glucose biosensors, including thickness characteristics and line-width effects on detection limits, linear range and interference immunity with membranes coated by micropipette/spin-coating and focus-ion-beam (FIB) processed capillary atomic-force-microscopy (C-AFM) tip scan/coating methods. The PSW surface was modified with a mixture of 3-aminopropyl-triethoxysilane (γ-APTES) and polydimethylsiloxane (PDMS)-treated hydrophobic fumed silica nanoparticles (NPs). We found that the thickness of the γ-APTES+NPs nonocomposite could be controlled well at about 22 nm with small relative standard deviation (RSD) with repeated C-AFM tip scan/coatings. The detection limit increased and linear range decreased with the line width of the PSW through the tip-coating process. Interestingly, the interference immunity ability improves as the line width increases. For a 500 nm-wide PSW, the percentage changes of the channel current density changes (ΔJ) caused by acetaminophen (AP) can be kept below 3.5% at an ultra-high AP-to-glucose concentration ratio of 600:1. Simulation results showed that the line width dependence of interference immunity was strongly correlated with the channel electrical field of the PSW biosensor. View Full-Text
Keywords: line width dependence; polysilicon wire; γ-APTES; PDMS; silica nanoparticles line width dependence; polysilicon wire; γ-APTES; PDMS; silica nanoparticles
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lin, J.-J.; Hsu, P.-Y.; Wu, Y.-L.; Jhuang, J.-J. Characteristics of Polysilicon Wire Glucose Sensors with a Surface Modified by Silica Nanoparticles/γ-APTES Nanocomposite. Sensors 2011, 11, 2796-2808.

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