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Sensors 2011, 11(1), 180-206; doi:10.3390/s110100180
Review

In Vivo Bioluminescent Imaging (BLI): Noninvasive Visualization and Interrogation of Biological Processes in Living Animals

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Received: 14 November 2010; in revised form: 6 December 2010 / Accepted: 23 December 2010 / Published: 28 December 2010
(This article belongs to the Special Issue Sensors in Biomechanics and Biomedicine)
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Abstract: In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism.
Keywords: bacterial luciferase; bioluminescent imaging; BLI; firefly luciferase; Lux; Luc bacterial luciferase; bioluminescent imaging; BLI; firefly luciferase; Lux; Luc
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Close, D.M.; Xu, T.; Sayler, G.S.; Ripp, S. In Vivo Bioluminescent Imaging (BLI): Noninvasive Visualization and Interrogation of Biological Processes in Living Animals. Sensors 2011, 11, 180-206.

AMA Style

Close DM, Xu T, Sayler GS, Ripp S. In Vivo Bioluminescent Imaging (BLI): Noninvasive Visualization and Interrogation of Biological Processes in Living Animals. Sensors. 2011; 11(1):180-206.

Chicago/Turabian Style

Close, Dan M.; Xu, Tingting; Sayler, Gary S.; Ripp, Steven. 2011. "In Vivo Bioluminescent Imaging (BLI): Noninvasive Visualization and Interrogation of Biological Processes in Living Animals." Sensors 11, no. 1: 180-206.


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