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Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts
World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
Japan Science and Technology Agency, CREST, 1-1 Namiki, Tsukuba 305-0044, Japan
* Author to whom correspondence should be addressed.
Received: 17 June 2010; in revised form: 7 July 2010 / Accepted: 8 July 2010 / Published: 13 July 2010
Abstract: Of the known intelligently-operating systems, the majority can undoubtedly be classed as being of biological origin. One of the notable differences between biological and artificial systems is the important fact that biological materials consist mostly of chiral molecules. While most biochemical processes routinely discriminate chiral molecules, differentiation between chiral molecules in artificial systems is currently one of the challenging subjects in the field of molecular recognition. Therefore, one of the important challenges for intelligent man-made sensors is to prepare a sensing system that can discriminate chiral molecules. Because intermolecular interactions and detection at surfaces are respectively parts of supramolecular chemistry and interfacial science, chiral sensing based on supramolecular and interfacial concepts is a significant topic. In this review, we briefly summarize recent advances in these fields, including supramolecular hosts for color detection on chiral sensing, indicator-displacement assays, kinetic resolution in supramolecular reactions with analyses by mass spectrometry, use of chiral shape-defined polymers, such as dynamic helical polymers, molecular imprinting, thin films on surfaces of devices such as QCM, functional electrodes, FET, and SPR, the combined technique of magnetic resonance imaging and immunoassay, and chiral detection using scanning tunneling microscopy and cantilever technology. In addition, we will discuss novel concepts in recent research including the use of achiral reagents for chiral sensing with NMR, and mechanical control of chiral sensing. The importance of integration of chiral sensing systems with rapidly developing nanotechnology and nanomaterials is also emphasized.
Keywords: chiral sensing; supramolecular chemistry; interface; molecular recognition; nanotechnology; nanomaterial
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MDPI and ACS Style
Ariga, K.; Richards, G.J.; Ishihara, S.; Izawa, H.; Hill, J.P. Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts. Sensors 2010, 10, 6796-6820.
Ariga K, Richards GJ, Ishihara S, Izawa H, Hill JP. Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts. Sensors. 2010; 10(7):6796-6820.
Ariga, Katsuhiko; Richards, Gary J.; Ishihara, Shinsuke; Izawa, Hironori; Hill, Jonathan P. 2010. "Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts." Sensors 10, no. 7: 6796-6820.