Abstract: Poly(D,L-lactide) synthesis using tin(II) 2-ethylhexanoate initiated ring-opening polymerization (ROP) takes over 30 hours in bulk at 120 °C. The use of microwave makes the same bulk polymerization process with the same initiator much faster and energy saving, with a reaction time of about 30 minutes at 100 °C. Here, the poly(lactide) synthesis was done in a microwave reactor, using frequency of 2.45 GHz and maximal power of 150 W. The reaction temperature was controlled via infra-red system for in-bulk-measuring, and was maintained at 100 °C. Different molar ratios of monomer and initiator, [M]/[I], of 1,000, 5,000 and 10,000 were used. The achieved average molar masses for the obtained polymers (determined by gel permeation chromatography) were in the interval from 26,700 to 112,500 g/mol. The polydispersion index was from 2.436 to 3.425. For applicative purposes, the obtained material was purified during the procedure of microsphere preparation. Microspheres were obtained by spraying a fine fog of polymer (D,L-lactide) solution in tetrahydrofuran into the water solution of poly(vinyl alcohol) with intensive stirring.
Keywords: poly(D,L-lactide); novel microwave synthesis; ring-opening polymerization (ROP)
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Nikolic, L.; Ristic, I.; Adnadjevic, B.; Nikolic, V.; Jovanovic, J.; Stankovic, M. Novel Microwave-Assisted Synthesis of Poly(D,L-lactide): The Influence of Monomer/Initiator Molar Ratio on the Product Properties. Sensors 2010, 10, 5063-5073.
Nikolic L, Ristic I, Adnadjevic B, Nikolic V, Jovanovic J, Stankovic M. Novel Microwave-Assisted Synthesis of Poly(D,L-lactide): The Influence of Monomer/Initiator Molar Ratio on the Product Properties. Sensors. 2010; 10(5):5063-5073.
Nikolic, Ljubisa; Ristic, Ivan; Adnadjevic, Borivoj; Nikolic, Vesna; Jovanovic, Jelena; Stankovic, Mihajlo. 2010. "Novel Microwave-Assisted Synthesis of Poly(D,L-lactide): The Influence of Monomer/Initiator Molar Ratio on the Product Properties." Sensors 10, no. 5: 5063-5073.