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Sensors 2010, 10(5), 4541-4557; doi:10.3390/s100504541

Design Strategies for Aptamer-Based Biosensors

1
Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China
2
Suzhou Institute of Biomedical Engineering Technology, Chinese Academy of Science, Suzhou 215163, China
3
Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, China
4
School of Biotechnology and the Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
*
Author to whom correspondence should be addressed.
Received: 11 February 2010 / Revised: 1 April 2010 / Accepted: 4 April 2010 / Published: 4 May 2010
(This article belongs to the Section Biosensors)
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Abstract

Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications.
Keywords: aptamer; biosensor; design strategy aptamer; biosensor; design strategy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Han, K.; Liang, Z.; Zhou, N. Design Strategies for Aptamer-Based Biosensors. Sensors 2010, 10, 4541-4557.

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