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Design Strategies for Aptamer-Based Biosensors
AbstractAptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications.
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Han, K.; Liang, Z.; Zhou, N. Design Strategies for Aptamer-Based Biosensors. Sensors 2010, 10, 4541-4557.View more citation formats
Han K, Liang Z, Zhou N. Design Strategies for Aptamer-Based Biosensors. Sensors. 2010; 10(5):4541-4557.Chicago/Turabian Style
Han, Kun; Liang, Zhiqiang; Zhou, Nandi. 2010. "Design Strategies for Aptamer-Based Biosensors." Sensors 10, no. 5: 4541-4557.