Next Article in Journal
Glucose Biosensors: An Overview of Use in Clinical Practice
Previous Article in Journal
A Multipath Routing Protocol Based on Clustering and Ant Colony Optimization for Wireless Sensor Networks
Sensors 2010, 10(5), 4541-4557; doi:10.3390/s100504541

Design Strategies for Aptamer-Based Biosensors

1 Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China 2 Suzhou Institute of Biomedical Engineering Technology, Chinese Academy of Science, Suzhou 215163, China 3 Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, China 4 School of Biotechnology and the Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, China
* Author to whom correspondence should be addressed.
Received: 11 February 2010 / Revised: 1 April 2010 / Accepted: 4 April 2010 / Published: 4 May 2010
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [708 KB, uploaded 21 June 2014]   |  


Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications.
Keywords: aptamer; biosensor; design strategy aptamer; biosensor; design strategy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Han, K.; Liang, Z.; Zhou, N. Design Strategies for Aptamer-Based Biosensors. Sensors 2010, 10, 4541-4557.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert