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Sensors 2010, 10(4), 3126-3144; doi:10.3390/s100403126

Environmentally Sensitive Fluorescent Sensors Based on Synthetic Peptides

1,*  and 2
1 Biosensor group, CNRS / Université de Strasbourg, IREBS, Parc d'Innovation, Boulevard Sébastien Brandt, BP 10413, 67412 Illkirch cedex, France 2 Division of Molecular Physics, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden
* Author to whom correspondence should be addressed.
Received: 6 January 2010 / Revised: 27 February 2010 / Accepted: 24 March 2010 / Published: 31 March 2010
(This article belongs to the Special Issue Fluorescent Chemosensors)
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Biosensors allow the direct detection of molecular analytes, by associating a biological receptor with a transducer able to convert the analyte-receptor recognition event into a measurable signal. We review recent work aimed at developing synthetic fluorescent molecular sensors for a variety of analytes, based on peptidic receptors labeled with environmentally sensitive fluorophores. Fluorescent indicators based on synthetic peptides are highly interesting alternatives to protein-based sensors, since they can be synthesized chemically, are stable, and can be easily modified in a site-specific manner for fluorophore coupling and for immobilization on solid supports.
Keywords: peptide biosensors; environmentally-sensitive fluorophore peptide biosensors; environmentally-sensitive fluorophore
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Choulier, L.; Enander, K. Environmentally Sensitive Fluorescent Sensors Based on Synthetic Peptides. Sensors 2010, 10, 3126-3144.

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