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Sensors 2010, 10(4), 3126-3144; doi:10.3390/s100403126

Environmentally Sensitive Fluorescent Sensors Based on Synthetic Peptides

1,*  and 2
1 Biosensor group, CNRS / Université de Strasbourg, IREBS, Parc d'Innovation, Boulevard Sébastien Brandt, BP 10413, 67412 Illkirch cedex, France 2 Division of Molecular Physics, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden
* Author to whom correspondence should be addressed.
Received: 6 January 2010 / Revised: 27 February 2010 / Accepted: 24 March 2010 / Published: 31 March 2010
(This article belongs to the Special Issue Fluorescent Chemosensors)
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Biosensors allow the direct detection of molecular analytes, by associating a biological receptor with a transducer able to convert the analyte-receptor recognition event into a measurable signal. We review recent work aimed at developing synthetic fluorescent molecular sensors for a variety of analytes, based on peptidic receptors labeled with environmentally sensitive fluorophores. Fluorescent indicators based on synthetic peptides are highly interesting alternatives to protein-based sensors, since they can be synthesized chemically, are stable, and can be easily modified in a site-specific manner for fluorophore coupling and for immobilization on solid supports.
Keywords: peptide biosensors; environmentally-sensitive fluorophore peptide biosensors; environmentally-sensitive fluorophore
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Choulier, L.; Enander, K. Environmentally Sensitive Fluorescent Sensors Based on Synthetic Peptides. Sensors 2010, 10, 3126-3144.

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