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Stress Sensors and Signal Transducers in Cyanobacteria
Laboratory of Intracellular Regulation, Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya street 35, 127276, Moscow, Russia
Department of Genetics, Faculty of Biology, Moscow State University, Moscow, Russia
* Author to whom correspondence should be addressed.
Received: 20 January 2010; in revised form: 15 February 2010 / Accepted: 3 March 2010 / Published: 23 March 2010
Abstract: In living cells, the perception of environmental stress and the subsequent transduction of stress signals are primary events in the acclimation to changes in the environment. Some molecular sensors and transducers of environmental stress cannot be identified by traditional and conventional methods. Based on genomic information, a systematic approach has been applied to the solution of this problem in cyanobacteria, involving mutagenesis of potential sensors and signal transducers in combination with DNA microarray analyses for the genome-wide expression of genes. Forty-five genes for the histidine kinases (Hiks), 12 genes for serine-threonine protein kinases (Spks), 42 genes for response regulators (Rres), seven genes for RNA polymerase sigma factors, and nearly 70 genes for transcription factors have been successfully inactivated by targeted mutagenesis in the unicellular cyanobacterium Synechocystis sp. PCC 6803. Screening of mutant libraries by genome-wide DNA microarray analysis under various stress and non-stress conditions has allowed identification of proteins that perceive and transduce signals of environmental stress. Here we summarize recent progress in the identification of sensory and regulatory systems, including Hiks, Rres, Spks, sigma factors, transcription factors, and the role of genomic DNA supercoiling in the regulation of the responses of cyanobacterial cells to various types of stress.
Keywords: histidine kinase; response regulator; sensor; serine-threonine kinase; stress; supercoiling; transducer
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Los, D.A.; Zorina, A.; Sinetova, M.; Kryazhov, S.; Mironov, K.; Zinchenko, V.V. Stress Sensors and Signal Transducers in Cyanobacteria. Sensors 2010, 10, 2386-2415.
Los DA, Zorina A, Sinetova M, Kryazhov S, Mironov K, Zinchenko VV. Stress Sensors and Signal Transducers in Cyanobacteria. Sensors. 2010; 10(3):2386-2415.
Los, Dmitry A.; Zorina, Anna; Sinetova, Maria; Kryazhov, Sergey; Mironov, Kirill; Zinchenko, Vladislav V. 2010. "Stress Sensors and Signal Transducers in Cyanobacteria." Sensors 10, no. 3: 2386-2415.