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Sensors 2010, 10(2), 1279-1290; doi:10.3390/s100201279

Direct Electrochemistry and Electrocatalysis of Hemoglobin at Mesoporous Carbon Modified Electrode

2,*  and 1,*
Received: 30 November 2009 / Revised: 30 December 2009 / Accepted: 18 January 2010 / Published: 3 February 2010
(This article belongs to the Section Biosensors)
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The novel highly ordered mesoporous carbon (known as FDU-15), prepared by the organic-organic self-assembly method was been used for first time for the immobilization of hemoglobin (Hb) and its bioelectrochemical properties were studied. The resulting Hb/FDU-15 film provided a favorable microenvironment for Hb to perform direct electron transfers at the electrode. The immobilized Hb also displayed its good electrocatalytic activity for the reduction of hydrogen peroxide. The results demonstrate that mesoporous carbon FDU-15 can improve the Hb loading with retention of its bioactivity and greatly promote the direct electron transfer, which can be attributed to its high specific surface area, uniform ordered porous structure, suitable pore size and biocompatibility. Our present study may provide an alternative way for the construction of nanostructure biofunctional surfaces and pave the way for its application to biosensors.
Keywords: hemoglobin; mesoporous carbon; direct electron transfer hemoglobin; mesoporous carbon; direct electron transfer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pei, S.; Qu, S.; Zhang, Y. Direct Electrochemistry and Electrocatalysis of Hemoglobin at Mesoporous Carbon Modified Electrode. Sensors 2010, 10, 1279-1290.

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