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Sensors 2010, 10(12), 10936-10952; doi:10.3390/s101210936

Estimating Plasma Glucose from Interstitial Glucose: The Issue of Calibration Algorithms in Commercial Continuous Glucose Monitoring Devices

1
Instituto Universitario de Automática e Informática Industrial, Universidad Politécnica de Valencia, Camino de Vera, s/n, 46022 Valencia, Spain
2
Dipartimento di Medicina Interna, Scienze Endocrine e Metaboliche, Università degli Studi di Perugia, Perugia, Italy
3
Institut d’Informatica i Aplicacions, Universitat de Girona/Campus Montilivi, Girona, Spain
*
Author to whom correspondence should be addressed.
Received: 4 September 2010 / Revised: 22 September 2010 / Accepted: 25 November 2010 / Published: 3 December 2010
(This article belongs to the Special Issue Glucose Sensors)
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Abstract

Evaluation of metabolic control of diabetic people has been classically performed measuring glucose concentrations in blood samples. Due to the potential improvement it offers in diabetes care, continuous glucose monitoring (CGM) in the subcutaneous tissue is gaining popularity among both patients and physicians. However, devices for CGM measure glucose concentration in compartments other than blood, usually the interstitial space. This means that CGM need calibration against blood glucose values, and the accuracy of the estimation of blood glucose will also depend on the calibration algorithm. The complexity of the relationship between glucose dynamics in blood and the interstitial space, contrasts with the simplistic approach of calibration algorithms currently implemented in commercial CGM devices, translating in suboptimal accuracy. The present review will analyze the issue of calibration algorithms for CGM, focusing exclusively on the commercially available glucose sensors. View Full-Text
Keywords: continuous glucose monitoring; calibration algorithms continuous glucose monitoring; calibration algorithms
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Rossetti, P.; Bondia, J.; Vehí, J.; Fanelli, C.G. Estimating Plasma Glucose from Interstitial Glucose: The Issue of Calibration Algorithms in Commercial Continuous Glucose Monitoring Devices. Sensors 2010, 10, 10936-10952.

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