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Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations
West University of Timisoara, 4 V. Parvan Ave, Timisoara 300223 Timis, Romania
National Institute of Research and Development for Isotopic and Molecular Technologies, 65-103 Donath Street 400293, Cluj-Napoca, Romania
Technical University of Cluj-Napoca, Faculty of Science and Materials Engineering, 28 Memorandumului Street, 400114, Cluj-Napoca, Romania
Victor Babes University of Medicine and Pharmacy Timisoara, Revolutiei Ave. No. 9, Timisoara, Romania
Institute of Chemistry—Timişoara of Romanian Academy, 24 M. Viteazul Ave, 300223-Timisoara, Romania
* Author to whom correspondence should be addressed.
Received: 8 July 2010; in revised form: 14 September 2010 / Accepted: 19 September 2010 / Published: 28 September 2010
Abstract: Two manganese(III) porphyrins: manganese(III) tetraphenylporphyrin chloride and manganese(III)-tetrakis(3-hydroxyphenyl)porphyrin chloride were tested as ionophores for the construction of new diclofenac−selective electrodes. The electroactive material was incorporated either in PVC or a sol−gel matrix. The effect of different plasticizers and additives (anionic and cationic) on the potentiometric response was studied. The best results were obtained for the PVC membrane plasticized with dioctylphtalate and having sodium tetraphenylborate as a lipophilic anionic additive incorporated. The sensor response was linear in the concentration range 3 × 10−6 – 1 × 10−2 M with a slope of −59.7 mV/dec diclofenac, a detection limit of 1.5 × 10−6 M and very good selectivity coefficients. It was used for the determination of diclofenac in pharmaceutical preparations, by direct potentiometry. The results were compared with those obtained by the HPLC reference method and a good agreement was found between the two methods.
Keywords: diclofenac; manganese porphyrins; ion–selective electrodes; potentiometry; electrochemical impedance spectroscopy; pharmaceuticals
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Vlascici, D.; Pruneanu, S.; Olenic, L.; Pogacean, F.; Ostafe, V.; Chiriac, V.; Pica, E.M.; Bolundut, L.C.; Nica, L.; Fagadar-Cosma, E. Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations. Sensors 2010, 10, 8850-8864.
Vlascici D, Pruneanu S, Olenic L, Pogacean F, Ostafe V, Chiriac V, Pica EM, Bolundut LC, Nica L, Fagadar-Cosma E. Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations. Sensors. 2010; 10(10):8850-8864.
Vlascici, Dana; Pruneanu, Stela; Olenic, Liliana; Pogacean, Florina; Ostafe, Vasile; Chiriac, Vlad; Pica, Elena Maria; Bolundut, Liviu Calin; Nica, Luminita; Fagadar-Cosma, Eugenia. 2010. "Manganese(III) Porphyrin-based Potentiometric Sensors for Diclofenac Assay in Pharmaceutical Preparations." Sensors 10, no. 10: 8850-8864.