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Open AccessCommunication
Molbank 2018, 2018(1), M981; https://doi.org/10.3390/M981

A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride

1
Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, Vernadsky ave. 86, 119571 Moscow, Russia
2
Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev ave. 8, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Received: 22 January 2018 / Revised: 12 February 2018 / Accepted: 16 February 2018 / Published: 18 February 2018
(This article belongs to the Section Organic Synthesis)
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Abstract

The absence of highly effective delivery systems is a major challenge for gene therapy. Our work was aimed at the development of novel cationic liposomes possessing high transfection efficiency. For this purpose, a novel disulfide polycationic amphiphile 2S4 was synthesized. Cationic liposomes based on 2S4 and a helper lipid DOPE were formed by the thin film hydration method and exhibited effective plasmid DNA delivery into the HEK293 cells, with a transfection activity superior to that of the commercial agent Lipofectamine® 2000. Our results suggest that the polycationic amphiphile 2S4 is a promising candidate for in vitro nucleic acid delivery. View Full-Text
Keywords: redox-sensitive; disulfide linker; gemini amphiphiles; cationic liposomes; gene therapy redox-sensitive; disulfide linker; gemini amphiphiles; cationic liposomes; gene therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Puchkov, P.A.; Shmendel, E.V.; Andreeva, V.D.; Morozova, N.G.; Zenkova, M.A.; Maslov, M.A. A Novel Disulfide-Containing Polycationic Amphiphile: 1,28-Di[(cholest-5-en-3β-yl)disulfanyl]-4,25-dioxo-3,8,12,17,21,26-hexaazaoctacosane Tetrahydrochloride. Molbank 2018, 2018, M981.

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