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Molbank, Volume 2018, Issue 1 (March 2018)

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Editorial

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Open AccessEditorial Acknowledgement to Reviewers of Molbank in 2017
Molbank 2018, 2018(1), M972; doi:10.3390/M972
Received: 9 January 2018 / Accepted: 9 January 2018 / Published: 9 January 2018
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Abstract
Peer review is an essential part in the publication process, ensuring that Molbank maintains high quality standards for its published papers. In 2017, a total of 46 papers were published in the journal.[...] Full article

Research

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Open AccessCommunication Synthesis of All Stereoisomers of 1-(4-Methoxyphenyl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide
Molbank 2018, 2018(1), M973; doi:10.3390/M973
Received: 6 December 2017 / Revised: 6 January 2018 / Accepted: 8 January 2018 / Published: 10 January 2018
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Abstract
In this study, all four stereoisomers of tryptoline or tetrahydro-β-carboline were synthesized in high yields by the catalyst-free amidation of methyl ester using methylamine under mild conditions. All isomers of the obtained amide and the precursor methyl ester were subjected to cell viability
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In this study, all four stereoisomers of tryptoline or tetrahydro-β-carboline were synthesized in high yields by the catalyst-free amidation of methyl ester using methylamine under mild conditions. All isomers of the obtained amide and the precursor methyl ester were subjected to cell viability measurements on HeLa cells. The results indicated that the stereochemistry of the derivatives is clearly related to cell viability. Full article
(This article belongs to the Section Organic Synthesis)
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Open AccessCommunication 3-[2-(Oxiran-2-yl)ethyl]-1-{4-[(2-oxiran-2-yl)ethoxy]benzyl}imidazolium bis(Trifluoromethane)sulfonimide
Molbank 2018, 2018(1), M974; doi:10.3390/M974
Received: 19 December 2017 / Revised: 9 January 2018 / Accepted: 10 January 2018 / Published: 13 January 2018
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Abstract
The synthesis of 3-[2-(oxiran-2-yl)ethyl]-1-{4-[(2-oxiran-2-yl)ethoxy]benzyl}imidazolium bis(trifluoromethane)sulfonimide was achieved in seven steps with an overall yield of 63%. This ionic liquid monomer is based on an imidazolium core containing a phenoxy moiety and aliphatic chains with a reactive epoxide at both ends. This imidazolium was
[...] Read more.
The synthesis of 3-[2-(oxiran-2-yl)ethyl]-1-{4-[(2-oxiran-2-yl)ethoxy]benzyl}imidazolium bis(trifluoromethane)sulfonimide was achieved in seven steps with an overall yield of 63%. This ionic liquid monomer is based on an imidazolium core containing a phenoxy moiety and aliphatic chains with a reactive epoxide at both ends. This imidazolium was obtained by an efficient, reproducible, and scalable synthesis from inexpensive reagents. In the last step, a powerful oxidative agent was successfully used to generate two epoxy functions with only acetone as a byproduct. The monomer structure and intermediates were analyzed by NMR experiments, infrared, and mass spectra. In addition, the thermal properties of the diepoxide were evaluated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Full article
(This article belongs to the Special Issue Heterocycles)
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Other

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Open AccessShort Note N-(3-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine
Molbank 2018, 2018(1), M975; doi:10.3390/M975
Received: 3 January 2018 / Revised: 16 January 2018 / Accepted: 16 January 2018 / Published: 19 January 2018
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Abstract
The two precursors 3-chloro-2-methylphenylthiourea 2 and 4-fluorophenacyl bromide 4 are reacted under Hantzsch thiazole synthesis condition to yield the new compound N-(3-chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine 5. The IR, 1H-NMR, 13C-NMR and mass spectral data are presented, along with its in vitro antibacterial
[...] Read more.
The two precursors 3-chloro-2-methylphenylthiourea 2 and 4-fluorophenacyl bromide 4 are reacted under Hantzsch thiazole synthesis condition to yield the new compound N-(3-chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine 5. The IR, 1H-NMR, 13C-NMR and mass spectral data are presented, along with its in vitro antibacterial activity against Staphylococcus aureus and Chromobacterium violaceum. Full article
(This article belongs to the Section Organic Synthesis)
Figures

Open AccessShort Note N-(3-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine
Molbank 2018, 2018(1), M976; doi:10.3390/M976 (registering DOI)
Received: 3 January 2018 / Revised: 16 January 2018 / Accepted: 16 January 2018 / Published: 23 January 2018
PDF Full-text (323 KB) | Supplementary Files
Abstract
The two precursors 3-chloro-2-methylphenylthiourea 2 and 4-fluorophenacyl bromide 4 are reacted under Hantzsch thiazole synthesis condition to yield the new compound N-(3-chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine 5. The IR, 1H-NMR, 13C-NMR and mass spectral data are presented, along with its in vitro antibacterial
[...] Read more.
The two precursors 3-chloro-2-methylphenylthiourea 2 and 4-fluorophenacyl bromide 4 are reacted under Hantzsch thiazole synthesis condition to yield the new compound N-(3-chloro-2-methylphenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine 5. The IR, 1H-NMR, 13C-NMR and mass spectral data are presented, along with its in vitro antibacterial activity against Staphylococcus aureus and Chromobacterium violaceum. Full article
(This article belongs to the Special Issue Heterocycles)
Figures

Open AccessShort Note 5-Amino-3-methyl-1,2,4-thiadiazole
Molbank 2018, 2018(1), M977; doi:10.3390/M977
Received: 12 December 2017 / Revised: 11 January 2018 / Accepted: 19 January 2018 / Published: 21 January 2018
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Abstract
An improved procedure for isolation of 5-amino-3-methyl-1,2,4-thiadiazole in pure form on a multi-gram scale without chromatography is reported. Its 1H and 13C-NMR and IR data are presented and previously published erroneous data corrected. The molecular structure is confirmed by X-ray diffraction
[...] Read more.
An improved procedure for isolation of 5-amino-3-methyl-1,2,4-thiadiazole in pure form on a multi-gram scale without chromatography is reported. Its 1H and 13C-NMR and IR data are presented and previously published erroneous data corrected. The molecular structure is confirmed by X-ray diffraction which shows layers consisting of an elaborate two-dimensional hydrogen bonded network of molecules. Full article
(This article belongs to the Special Issue Heterocycles)
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