A section of Molbank (ISSN 1422-8599).
Following special issues within this section are currently open for submissions:
- Heterocycles (Deadline: 31 December 2017)
- Molecules from Catalytic Cyclization Processes (Deadline: 31 January 2018)
- Photocatalysis (Deadline: 15 February 2018)
(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione – Synthesis, Crystallographic Studies and Biological Activity Screening
Adam Mieczkowski, Maciej Bagiński, Bartosz Bieszczad, Magdalena Mroczkowska, Marcin Wilczek
(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione was obtained in a three step, one-pot synthesis starting from optically pure (S)-2-piperazinecarboxylic acid dihydrochloride. The selective acylation of β nitrogen atom followed by condensation with isatoic anhydride and cyclization with HATU/DIPEA system to 7-member benzodiazepine ring led to the tricyclic benzodiazepine derivative. The crystallographic studies and initial biological screening were performed for titled compound.
4-(Bis((3,5-dimethyl-1H-pyrazol-1-yl) methyl) amino) Benzonitrile
Yassine Kaddouri, Abdelillah Takfaoui1, Rafika El Ati, Farid Abrigach and Rachid Touzani
Tridentate pyrazolic ligands are very interested for several applications, we have synthetized 4-(bis((3,5-dimethyl-1H-pyrazol-1-yl) methyl) amino) benzonitrile (L1); which is N-C-N linked type; with good yield of 97% after that its purified, then we verify the structure by several physicochemical methods as 1H NMR, 13C NMR, FTIR and MS.