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Organic Synthesis

A section of Molbank (ISSN 1422-8599).

Section Information

This section of Molbank covers the traditional core domain of the journal. It is dedicated to the rapid publication of “one-compound-per-paper short notes” that describe the preparation and characterization of new compounds that may belong to any product class within organic chemistry. Submissions should contain an element of novelty in order to successfully pass the reviewing process. Manuscripts describing the synthesis of a known compound are considered only in very rare, exceptional cases if both of the following criteria are met: (a) the compound must be of extraordinary general interest; and (b) its synthesis was significantly improved. All types of newly synthesized organic compounds that can be defined as single chemical entities with a unique systematic name (following the IUPAC naming rules) are welcome. Besides “short notes”, articles of the “Communication” type will also be considered. They are not restricted to a single compound per paper and their title can be freely chosen. However, for such manuscripts there will be a stronger focus on novelty and originality in the reviewing process. As is the case for all other types of Molbank articles, submissions must be accompanied with a valid 2D molfile and relevant characterization data to be provided to reviewers and readers as supplementary material (see instructions for authors ).


Organic synthesis; organic reaction; one-step synthesis; reaction mechanism; characterization; structure elucidation; biological activity

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Special Issues

Following special issues within this section are currently open for submissions:

Papers Published

Upcoming Papers

(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione – Synthesis, Crystallographic Studies and Biological Activity Screening

Adam Mieczkowski, Maciej Bagiński, Bartosz Bieszczad, Magdalena Mroczkowska, Marcin Wilczek


(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione was obtained in a three step, one-pot synthesis starting from optically pure (S)-2-piperazinecarboxylic acid dihydrochloride. The selective acylation of β nitrogen atom followed by condensation with isatoic anhydride and cyclization with HATU/DIPEA system to 7-member benzodiazepine ring led to the tricyclic benzodiazepine derivative. The crystallographic studies and initial biological screening were performed for titled compound.

4-(Bis((3,5-dimethyl-1H-pyrazol-1-yl) methyl) amino) Benzonitrile

Yassine Kaddouri, Abdelillah Takfaoui1, Rafika El Ati, Farid Abrigach and Rachid Touzani


Tridentate pyrazolic ligands are very interested for several applications, we have synthetized 4-(bis((3,5-dimethyl-1H-pyrazol-1-yl) methyl) amino) benzonitrile (L1); which is N-C-N linked type; with good yield of 97% after that its purified, then we verify the structure by several physicochemical methods as 1H NMR, 13C NMR, FTIR and MS.

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Fax: +41 61 302 89 18
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