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Molbank 2017, 2017(4), M968; https://doi.org/10.3390/M968

1,3-Bis(1,2,4-triazol-1-yl)adamantane

Department of Biotechnology and Organic Chemistry, National Research Tomsk Polytechnic University, 30 Lenin Ave., 634050 Tomsk, Russia
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Received: 3 December 2017 / Revised: 8 December 2017 / Accepted: 11 December 2017 / Published: 12 December 2017
(This article belongs to the Section Organic Synthesis)
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Abstract

Functional adamantane derivatives are interesting as active pharmaceutical ingredients, building blocks for supramolecular ensembles, and ligands in light of the coordination chemistry of functional materials. In this communication, synthesis of two isomeric 1,3-bis(1,2,4-triazolyl)adamantanes by the reaction of 1,3-dibromoadamantane with 1,2,4-triazole in the absence of solvent is reported. The products, namely 1,3-bis(1,2,4-triazol-1-yl)adamantane and 1-(1,2,4-triazol-1-yl)-3-(1,2,4-triazol-4-yl)adamantane were separated by column chromatography and identified by NMR and mass-spectrometry. View Full-Text
Keywords: 1,2,4-triazole; adamantane; alkylation; bitopic ligand; adamantylation; substitution reaction 1,2,4-triazole; adamantane; alkylation; bitopic ligand; adamantylation; substitution reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Marchenko, R.; Potapov, A. 1,3-Bis(1,2,4-triazol-1-yl)adamantane. Molbank 2017, 2017, M968.

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