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Molbank 2017, 2017(1), M923; doi:10.3390/M923


Department of Chemistry, University of Cyprus, P. O. Box 20537, Nicosia 1678, Cyprus
Author to whom correspondence should be addressed.
Academic Editor: Norbert Haider
Received: 1 December 2016 / Revised: 22 December 2016 / Accepted: 26 December 2016 / Published: 29 December 2016
(This article belongs to the Section Organic Synthesis)
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4,6-Dichloro-2-(methylthio)pyrimidine (3) reacts with EtONa in EtOH, at ca. 20 °C, for 2 h, to give exclusively 4-chloro-6-ethoxy-2-(methylthio)pyrimidine (5) in 89% yield. The latter is presented as a useful multifunctionalised pyrimidine scaffold. View Full-Text
Keywords: heterocycle; pyrimidine; multifunctionalised heterocycle; pyrimidine; multifunctionalised

Scheme 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kalogirou, A.S.; Koutentis, P.A. 4-Chloro-6-ethoxy-2-(methylthio)pyrimidine. Molbank 2017, 2017, M923.

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