Next Article in Journal
4,5-Dimethylbenzene-1,2-dimethanol
Previous Article in Journal
N2-tert-Butoxycarbonyl-N5-[N-(9-fluorenylmethyloxycarbonyl)-2-aminoethyl]-(S)-2,5-diaminopentanoic Acid
Molbank 2014, 2014(3), M834; doi:10.3390/M834
Short Note

(R)-(−)-2-[(5-Oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin-12-yl)amino]benzonitrile

,  and *
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany
* Author to whom correspondence should be addressed.
Received: 25 July 2014 / Accepted: 19 August 2014 / Published: 26 August 2014
Download PDF [781 KB, uploaded 26 August 2014]

Abstract

Copper-catalyzed cross-coupling between (S)-S-methyl-S-phenylsulfoximine (1) and 2-iodobenzonitrile (2) resulted in the discovery of an unprecedented one-pot triple arylation sequence to give (R)-(−)-2-[(5-oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin- 12-yl)amino]benzonitrile (4). Here, we describe the synthesis of the title compound (R)-4 and the elucidation of its structure by means of various techniques.
Keywords: sulfoximines; benzothiazines; arylation; copper catalysis sulfoximines; benzothiazines; arylation; copper catalysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Frings, M.; Atodiresei, I.; Bolm, C. (R)-(−)-2-[(5-Oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin-12-yl)amino]benzonitrile. Molbank 2014, 2014, M834.

View more citation formats

Supplements

Article Metrics

Comments

Citing Articles

[Return to top]
Molbank EISSN 1422-8599 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert