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Molbank 2014, 2014(3), M832; doi:10.3390/M832

Chitooligosaccharide-2,5-anhydro-D-mannonic Acid

Ingénierie des Matériaux Polymères (IMP, UMR CNRS 5223), Université Claude Bernard Lyon 1, Université de Lyon, Villeurbanne F-69622, France
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Received: 26 June 2014 / Accepted: 14 August 2014 / Published: 19 August 2014
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Abstract

Chitooligosaccharide with one 2,5-anhydro-D-mannofuranose unit at the reducing end (COSamf) was prepared by nitrous deamination of fully N-deacetylated chitosan. The oxidation of the amf-unit by chlorite sodium was achieved in high yield. The chemical structure of the targeted chitooligosaccharide-2,5-anhydro-D-mannonic acid with a degree of polymerization ~10 was fully characterized by NMR spectroscopy, MALDI-TOF mass spectrometry and size-exclusion chromatography. The success of this synthesis opens the way to a new generation of end-functionalized COS building blocks.
Keywords: chitosan; chitooligosaccharide-2,5-anhydro-D-mannofuranose; 2,5-anhydro-D-mannonic acid; nitrous deamination; oxidation chitosan; chitooligosaccharide-2,5-anhydro-D-mannofuranose; 2,5-anhydro-D-mannonic acid; nitrous deamination; oxidation
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Salim, E.; Ailincai, D.; Trombotto, S. Chitooligosaccharide-2,5-anhydro-D-mannonic Acid. Molbank 2014, 2014, M832.

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