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3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride
Molbank 2012, 2012(3), M772; doi:10.3390/M772
Short Note

2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III)

*  and
Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstra├če 14, A- 1090 Vienna, Austria
* Author to whom correspondence should be addressed.
Received: 27 June 2012 / Accepted: 13 August 2012 / Published: 24 August 2012
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An hydroxypropyl-aziridine-containing side chain is attached to an oxonaphthalene-annelated pyrrole in expectation of DNA alkylating properties. The cytotoxicity is evaluated against two cell lines, KB-31 and KB-8511, respectively.
Keywords: pyrrole; DNA-alkylation; anticancer pyrrole; DNA-alkylation; anticancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Spreitzer, H.; Puschmann, C. 2-[3-(Aziridin-1-yl)-2-hydroxypropyl]-5,5-dimethyl-2,5-dihydro-4H-benzo[e]isoindol-4-one (Cytotoxic Oxonaphthalene-Pyrroles, Part III). Molbank 2012, 2012, M772.

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