3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride

doi:10.3390/M771

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Molbank 2012, 2012(3), M771; doi:10.3390/M771

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3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride

Rajagopalan Srinivasan^1,2, Badiadka Narayana^1,* , Seranthimata Samshuddin¹ and Balladka Kunhanna Sarojini³

¹ Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India ² Aurigene Discovery Technologies Limited, Electronics city, Phase-II, Bangalore-560 100, Karnataka, India ³ Research Department of Chemistry, P. A College of Engineering, Nadupadavu, Mangalore 574153, Karnataka, India

* Author to whom correspondence should be addressed.

Received: 29 June 2012 / Accepted: 15 August 2012 / Published: 17 August 2012

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Abstract: A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N-arylation of pyrazolone (1) using copper(I) iodide catalyst followed by reduction to give amine (2). The coupling of 2 with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (3).

Keywords: spirocyclic; pyrazolone; reduction; N-arylation; amide coupling

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Cite This Article

MDPI and ACS Style

Srinivasan, R.; Narayana, B.; Samshuddin, S.; Sarojini, B.K. 3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride. Molbank 2012, 2012, M771.

AMA Style

Srinivasan R, Narayana B, Samshuddin S, Sarojini BK. 3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride. Molbank. 2012; 2012(3):M771.

Chicago/Turabian Style

Srinivasan, Rajagopalan; Narayana, Badiadka; Samshuddin, Seranthimata; Sarojini, Balladka Kunhanna. 2012. "3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride." Molbank 2012, no. 3: M771.

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