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Molbank 2012, 2012(3), M771; doi:10.3390/M771
Short Note

3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride

1,2, 1,* , 1 and 3
1 Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India 2 Aurigene Discovery Technologies Limited, Electronics city, Phase-II, Bangalore-560 100, Karnataka, India 3 Research Department of Chemistry, P. A College of Engineering, Nadupadavu, Mangalore 574153, Karnataka, India
* Author to whom correspondence should be addressed.
Received: 29 June 2012 / Accepted: 15 August 2012 / Published: 17 August 2012
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A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N-arylation of pyrazolone (1) using copper(I) iodide catalyst followed by reduction to give amine (2). The coupling of 2 with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (3).
Keywords: spirocyclic; pyrazolone; reduction; N-arylation; amide coupling spirocyclic; pyrazolone; reduction; N-arylation; amide coupling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Srinivasan, R.; Narayana, B.; Samshuddin, S.; Sarojini, B.K. 3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride. Molbank 2012, 2012, M771.

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