4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride

doi:10.3390/M773

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Molbank 2012, 2012(3), M773; doi:10.3390/M773

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4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride

Rajagopalan Srinivasan^1,2, Badiadka Narayana^1,* , Seranthimata Samshuddin¹ and Balladka Kunhanna Sarojini³

¹ Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India ² Aurigene Discovery Technologies Limited, Electronics city, Phase-II, Bangalore-560 100, Karnataka, India ³ Research Department of Chemistry, P. A College of Engineering, Nadupadavu, Mangalore 574153, Karnataka, India

* Author to whom correspondence should be addressed.

Received: 3 July 2012 / Accepted: 21 August 2012 / Published: 24 August 2012

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Abstract: A novel route for the synthesis of new spirocyclic derivative is developed. The present work involves the synthesis of title compound 3 by Suzuki coupling of 3,5-difluorophenyl boronic acid with tert-butyl 1-(5-bromofuran-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate (2), which in turn prepared from the ethyl nipecotate (1). Newly prepared spirocyclic derivative (3) is characterized by IR, NMR and mass spectral data.

Keywords: spirocyclic; pyrazolone; Suzuki coupling; ethyl nipecotate

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Cite This Article

MDPI and ACS Style

Srinivasan, R.; Narayana, B.; Samshuddin, S.; Sarojini, B.K. 4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride. Molbank 2012, 2012, M773.

AMA Style

Srinivasan R, Narayana B, Samshuddin S, Sarojini BK. 4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride. Molbank. 2012; 2012(3):M773.

Chicago/Turabian Style

Srinivasan, Rajagopalan; Narayana, Badiadka; Samshuddin, Seranthimata; Sarojini, Balladka Kunhanna. 2012. "4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride." Molbank 2012, no. 3: M773.

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