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Int. J. Mol. Sci. 2008, 9(8), 1424-1434; doi:10.3390/ijms9081424

Redox Behavior of Anticancer Chalcone on a Glassy Carbon Electrode and Evaluation of its Interaction Parameters with DNA

Deprtment of Chmeistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan
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Received: 3 July 2008 / Revised: 23 July 2008 / Accepted: 23 July 2008 / Published: 13 August 2008
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The interaction of anticancer chalcone [AMC, 1-(4'-aminophenyl)-3-(4-N,Ndimethylphenyl)- 2-propen-1-one] with DNA has been explored using electrochemical, spectroscopic and viscometric techniques. A shift in peak potential and decrease in peak current were observed in cyclic voltammetry and hypochromism accompanied with bathochromic shift were noticed in UV-Vis absorption spectroscopy. These findings were taken as evidence for AMC –DNA intercalation. A binding constant (K) with a value of 6.15 × 105 M-1 was obtained from CV data, which was also confirmed by UV-Vis absorption titration. Moreover, the diffusion coefficient of the drug with and without DNA (Db and Du), heterogeneous electron transfer rate constant (ko) and electron affinity (A) were also calculated from electrochemical data.
Keywords: DNA; hypochromism; bathochromic shift; binding constant. DNA; hypochromism; bathochromic shift; binding constant.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shah, A.; Khan, A.M.; Qureshi, R.; Ansari, F.L.; Nazar, M.F.; Shah, S.S. Redox Behavior of Anticancer Chalcone on a Glassy Carbon Electrode and Evaluation of its Interaction Parameters with DNA. Int. J. Mol. Sci. 2008, 9, 1424-1434.

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