Next Article in Journal
Plant Products for Pharmacology: Application of Enzymes in Their Transformations
Next Article in Special Issue
Protein Folding and Misfolding on Surfaces
Previous Article in Journal
QSAR Study of Antimicrobial 3-Hydroxypyridine-4-one and 3-Hydroxypyran-4-one Derivatives Using Different Chemometric Tools
Previous Article in Special Issue
A Crosslinking Analysis of GAP-43 Interactions with Other Proteins in Differentiated N1E-115 Cells
Int. J. Mol. Sci. 2008, 9(12), 2424-2446; doi:10.3390/ijms9122424

Discovery of Proteomic Code with mRNA Assisted Protein Folding

Homulus Foundation, 612 S Flower St, Los Angeles, 90 017 CA, USA
Received: 18 August 2008 / Revised: 24 November 2008 / Accepted: 2 December 2008 / Published: 3 December 2008
(This article belongs to the Special Issue Protein Folding)
View Full-Text   |   Download PDF [1241 KB, uploaded 19 June 2014]   |   Browse Figures


The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is additional to the 64/20 definition of amino acids. It might define the physico-chemical and structural properties of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the coded proteins and the free folding energy of mRNAs. This additional information, which seems to be necessary to determine the 3D structure of coding nucleic acids as well as the coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding.
Keywords: Gene; code; codon; translation; wobble-base Gene; code; codon; translation; wobble-base
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Biro, J.C. Discovery of Proteomic Code with mRNA Assisted Protein Folding. Int. J. Mol. Sci. 2008, 9, 2424-2446.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert