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Int. J. Mol. Sci. 2007, 8(9), 894-919; doi:10.3390/i8090894
Article

Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors

1
, 1,* , 2
 and 3
Received: 2 May 2007; in revised form: 25 July 2007 / Accepted: 30 July 2007 / Published: 3 September 2007
(This article belongs to the Special Issue The Chemical Bond and Bonding)
Abstract: Flavoprotein monoamine oxidase is located on the outer membrane ofmitochondria. It catalyzes oxidative deamination of monoamine neurotransmitters such asserotonin, norepinephrine and dopamine and hence is a target enzyme for antidepressantdrugs. MAO (mono amine oxidase) has two isoforms, namely MAO-A and MAO-B.MAO-A isoform has higher affinity for serotonin and norepinephrine, while; MAO-Bpreferentially deaminates phenylethylamine and benzylamine. These important propertiesdetermine the clinical importance of MAO inhibitors. Selective MAO-A inhibitors are usedin the treatment of neurological disorders such as depression. In this article we havedeveloped a Hypogen pharmacophore for a set of 64 coumarin analogs and tried to analyzethe intermolecular H-bonds with receptor structure.
Keywords: MAO-A; pharmacophore; docking MAO-A; pharmacophore; docking
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sairam, K.V.; Khar, R.K.; Mukherjee, R.; Jain, S.K. Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors. Int. J. Mol. Sci. 2007, 8, 894-919.

AMA Style

Sairam KV, Khar RK, Mukherjee R, Jain SK. Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors. International Journal of Molecular Sciences. 2007; 8(9):894-919.

Chicago/Turabian Style

Sairam, Kalapatapu V.; Khar, Roop K.; Mukherjee, Rama; Jain, Swatantra K. 2007. "Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors." Int. J. Mol. Sci. 8, no. 9: 894-919.


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