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Int. J. Mol. Sci. 2007, 8(7), 695-704; doi:10.3390/i8070695
Article

Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N4-benzoyl Cytosine andN6-benzoyl Adenine

1, 2, 2, 1 and 1,*
1 Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece 2 Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, University of Thessaly, Larissa, Greece
* Author to whom correspondence should be addressed.
Received: 17 April 2007 / Revised: 12 June 2007 / Accepted: 15 June 2007 / Published: 20 July 2007
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Abstract

Fluorinated nucleoside analogues are known as antitumor, antiviral andchemotherapeutic agents, although the antioxidant activity of this kind of molecules is notyet investigated. In this study we have tested the antioxidant activity of a series of modifiedpyrano-nucleoside analogues using three in vitro assays. Firstly, the antioxidant capacity ofthe products was assessed using the DPPH assay and secondly, in order to examine theability of the products to protect DNA from the activity of reactive oxygen species (ROS),a peroxyl radical (ROO•) and a hydroxyl radical (OH•) induced DNA strand scission assaywere used. None of the molecules showed the ability to scavenge DPPH radical andprevent OH• induced DNA strand breakage. Although, most of the tested nucleosideanalogues, had the ability to prevent ROO• induced DNA damage.
Keywords: fluorinated nucleosides; antioxidants; DPPH; DNA damage; ROS. fluorinated nucleosides; antioxidants; DPPH; DNA damage; ROS.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Spanou, C.; Manta, S.; Komiotis, D.; Dervishi, A.; Kouretas, D. Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N4-benzoyl Cytosine andN6-benzoyl Adenine. Int. J. Mol. Sci. 2007, 8, 695-704.

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