Int. J. Mol. Sci. 2007, 8(7), 695-704; doi:10.3390/i8070695
Article

Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N4-benzoyl Cytosine andN6-benzoyl Adenine

1 Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece 2 Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, University of Thessaly, Larissa, Greece
* Author to whom correspondence should be addressed.
Received: 17 April 2007; in revised form: 12 June 2007 / Accepted: 15 June 2007 / Published: 20 July 2007
PDF Full-text Download PDF Full-Text [154 KB, uploaded 20 June 2008 16:51 CEST]
Abstract: Fluorinated nucleoside analogues are known as antitumor, antiviral andchemotherapeutic agents, although the antioxidant activity of this kind of molecules is notyet investigated. In this study we have tested the antioxidant activity of a series of modifiedpyrano-nucleoside analogues using three in vitro assays. Firstly, the antioxidant capacity ofthe products was assessed using the DPPH assay and secondly, in order to examine theability of the products to protect DNA from the activity of reactive oxygen species (ROS),a peroxyl radical (ROO•) and a hydroxyl radical (OH•) induced DNA strand scission assaywere used. None of the molecules showed the ability to scavenge DPPH radical andprevent OH• induced DNA strand breakage. Although, most of the tested nucleosideanalogues, had the ability to prevent ROO• induced DNA damage.
Keywords: fluorinated nucleosides; antioxidants; DPPH; DNA damage; ROS.

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Spanou, C.; Manta, S.; Komiotis, D.; Dervishi, A.; Kouretas, D. Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N4-benzoyl Cytosine andN6-benzoyl Adenine. Int. J. Mol. Sci. 2007, 8, 695-704.

AMA Style

Spanou C, Manta S, Komiotis D, Dervishi A, Kouretas D. Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N4-benzoyl Cytosine andN6-benzoyl Adenine. International Journal of Molecular Sciences. 2007; 8(7):695-704.

Chicago/Turabian Style

Spanou, Chrysoula; Manta, Stella; Komiotis, Dimitri; Dervishi, Albiona; Kouretas, Demetrios. 2007. "Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N4-benzoyl Cytosine andN6-benzoyl Adenine." Int. J. Mol. Sci. 8, no. 7: 695-704.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert