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• Spanou, C
• Manta, S
• Komiotis, D
• Dervishi, A
• Kouretas, D
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• Manta, S
• Komiotis, D
• Dervishi, A
• Kouretas, D
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• Manta, S
• Komiotis, D
• Dervishi, A
• Kouretas, D

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Int. J. Mol. Sci. 2007, 8(7), 695-704; doi:10.3390/i8070695

Article

Antioxidant Activity of a Series of FluorinatedPyrano-nucleoside Analogues of N⁴-benzoyl Cytosine andN⁶-benzoyl Adenine

Chrysoula Spanou¹ , Stella Manta² , Dimitri Komiotis² , Albiona Dervishi¹  and Demetrios Kouretas^1,*

¹ Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece ² Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, University of Thessaly, Larissa, Greece

* Author to whom correspondence should be addressed.

Received: 17 April 2007; in revised form: 12 June 2007 / Accepted: 15 June 2007 / Published: 20 July 2007

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Abstract: Fluorinated nucleoside analogues are known as antitumor, antiviral andchemotherapeutic agents, although the antioxidant activity of this kind of molecules is notyet investigated. In this study we have tested the antioxidant activity of a series of modifiedpyrano-nucleoside analogues using three in vitro assays. Firstly, the antioxidant capacity ofthe products was assessed using the DPPH assay and secondly, in order to examine theability of the products to protect DNA from the activity of reactive oxygen species (ROS),a peroxyl radical (ROO•) and a hydroxyl radical (OH•) induced DNA strand scission assaywere used. None of the molecules showed the ability to scavenge DPPH radical andprevent OH• induced DNA strand breakage. Although, most of the tested nucleosideanalogues, had the ability to prevent ROO• induced DNA damage.

Keywords: fluorinated nucleosides; antioxidants; DPPH; DNA damage; ROS.

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