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Int. J. Mol. Sci. 2007, 8(7), 564-571; doi:10.3390/i8070564
Article

DNA-Binding Study of Tetraaqua-bis(p-nitrobenzoato)cobalt(II) Dihydrate Complex: [Co(H2O)4(p-NO2C6H4COO)2]·2H2O

1,* , 2
 and
1
Received: 27 March 2007 / Revised: 25 May 2007 / Accepted: 4 June 2007 / Published: 27 June 2007
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The interaction of [Co(H2O)4(p-NO2C6H4COO)2]. 2H2O with sheep genomicDNA has been investigated by spectroscopic studies and electrophoresis measurements.The interaction between cobalt(II) p-nitrobenzoate and DNA has been followed by gelelectrophoresis while the concentration of the complex was increased from 0 to 14 mM.The spectroscopic study and electrophoretic experiments support the fact that the complexbinds to DNA by intercalation via p-nitrobenzoate into the base pairs of DNA. Themobility of the bands decreased as the concentration of complex was increased, indicatingthat there was increase in interaction between the metal ion and DNA.
Keywords: Cobalt(II) complexes; DNA-binding; p-nitrobenzoate Cobalt(II) complexes; DNA-binding; p-nitrobenzoate
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Arslantas, A.; Devrim, A.K.; Necefoglu, H. DNA-Binding Study of Tetraaqua-bis(p-nitrobenzoato)cobalt(II) Dihydrate Complex: [Co(H2O)4(p-NO2C6H4COO)2]·2H2O. Int. J. Mol. Sci. 2007, 8, 564-571.

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