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Int. J. Mol. Sci. 2007, 8(6), 492-504; doi:10.3390/i8060492

Changes in the Ratio of Tc1/Tc2 and Th1/Th2 Cells but Not in Subtypes of NK-Cells in Preeclampsia

1, 2, 1, 1, 1 and 2,*
1 Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, P. R. China 2 Immunology and Reproductive Biology Lab, Medical School, Nanjing University, Nanjing, 210093, P. R. China
* Author to whom correspondence should be addressed.
Received: 13 December 2006 / Revised: 30 April 2007 / Accepted: 25 May 2007 / Published: 8 June 2007
(This article belongs to the Special Issue Interaction of Biological Molecules)
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It has been suggested that natural killer (NK) cell activity and Th1 immunitymay be involved in the pathogenesis of preeclampsia. This study aimed to investigate theimmunophenotypes of NK cells and type 1/type 2 immunity in both decidua and maternalperipheral blood between normal (n=11) and preeclamptic pregnant women (n=20) by flowcytometry. The results showed that no significant difference was observed between patientsand controls by detecting CD56+ CD69+ and CD56+ CD94+ NK cells in both peripheralblood and decidua. Moreover, in preeclamptic patients, decreased percentages of Tc2 andTh2 cells and the increased ratios of Tc1/Tc2 were determined in both decidua andmaternal peripheral blood. In addition, the ratio of Th1/Th2 in peripheral blood alsoincreased. There was no significant difference of immunophenotypes of uNK cells betweenpreeclampsia and normal pregnancy. Local decidua and systematic immunity did notcorrelate with each other. These results suggest that the type 1/type 2 immunity shifted totype 1 immunity including Th1 and Tc1 cells may contribute to the patho-genesis ofpreeclampsia.
Keywords: Decidua; uNK cell; NK cell; type 1/type 2 immunity; preeclampsia; human Decidua; uNK cell; NK cell; type 1/type 2 immunity; preeclampsia; human
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hu, Y.; Zhou, J.; Hao, S.; Wang, Z.; Dai, Y.; Ling, J.; Hou, Y. Changes in the Ratio of Tc1/Tc2 and Th1/Th2 Cells but Not in Subtypes of NK-Cells in Preeclampsia. Int. J. Mol. Sci. 2007, 8, 492-504.

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