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Int. J. Mol. Sci. 2006, 7(11), 510-518; doi:10.3390/i7110510

Expression of Myosin Light Chain Kinase in Kidney of Streptozotocin-Induced Diabetic Rats

1,* , 2, 2, 2, 2, 1 and 1
Received: 2 October 2006 / Accepted: 13 November 2006 / Published: 21 November 2006
(This article belongs to the Special Issue Interaction of Biological Molecules)
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Nephropathy is one of the most common complications of diabetes mellituswhich remains incompletely understood. We reported the expression of myosin light chainkinase (MLCK) in the kidney of diabetic rats and investigated the correlation betweenMLCK and diabetic nephropathy by observing the expression of MLCK. The diabetic modelrats were induced by an intraperitoneal injection of streptozotocin (STZ) and the insulin-treated rats were subcutaneously injected with protamine zine insulin 3u/d. The kidneyswere excised and immersed in 4% polyoxymethylene after 12 weeks later. The expression ofMLCK was analyzed by immunohistochemical staining and Western blot.Immunohistochemical analysis and Western blot assay indicated that the MLCK expressionwas higher in kidney of diabetic rats than that in control and it was decreased in kidney ofinsulin-treated rats. Our results suggested that the over expression of MLCK may be relatedwith the development of diabetic nephropathy.
Keywords: myosin light chain kinase; diabetes nephropathy; insulin; rats myosin light chain kinase; diabetes nephropathy; insulin; rats
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Zhu, H.; Zhang, X.; Zuo, L.; Zhou, Q.; Gui, S.; Wei, W.; Wang, Y. Expression of Myosin Light Chain Kinase in Kidney of Streptozotocin-Induced Diabetic Rats. Int. J. Mol. Sci. 2006, 7, 510-518.

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