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Int. J. Mol. Sci. 2002, 3(9), 985-991; doi:10.3390/i3090985

Effect of Turmerin on Endothelial Denudation by Air Drying

1
Department of Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA
2
Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA
3
School of Health Related Professions, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, USA
*
Author to whom correspondence should be addressed.
Received: 7 June 2002 / Accepted: 30 September 2002 / Published: 30 September 2002
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Abstract

The objective of this study is to determine if arterial endothelial injury can be attenuated by local application of 80 μg/ml turmerin at the site of injury and by oral administration of the same dose. Anesthetized Lewis rats (n =12) weighing 200 ± 4.0 gms randomly were assigned to two groups. After 5 min of air drying a segment of right carotid artery, six rats were treated locally 80μg/ml with turmerin and the rest were treated with 0.9% NaCl. Turmerin was then administered by gavage (80 μg) every 24 hrs for 14 days. Animals were sacrificed on day 14 and the carotid artery removed from the injured site for histological analysis and serum collected for lipid peroxidation analysis by measuring malondialdehyde (MDA) and conjugated dienes. This study showed no proliferation in the intima of one rat out of six rats treated with turmerin while there was significant variation between the treated rats and the controls. MDA for control was 0.593±0.02 nanomoles/ml while turmerin was 0.187±0.04 (p≤0.01); conjugated diene for control was 0.402±0.03 nanomoles/ml while turmerin was 0.212±0.04 nanomoles/ml (p ≤0.05). Although there was significant reduction in serum peroxidation activity, the histological findings indicate that attenuation of carotid artery injury may involve other factors than decreased lipid peroxidation. View Full-Text
Keywords: Turmerin; lipid peroxidation; arterial injury; smooth muscle cells; endothelial cells Turmerin; lipid peroxidation; arterial injury; smooth muscle cells; endothelial cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Cohly, H.H.P.; Hammet, C.; Angel, M.F.; Kanji, V.; Taylor, A.; Benghuzzi, H.; Markov, A.K. Effect of Turmerin on Endothelial Denudation by Air Drying. Int. J. Mol. Sci. 2002, 3, 985-991.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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