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Int. J. Mol. Sci. 2018, 19(8), 2373; https://doi.org/10.3390/ijms19082373

The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer

Departments of Biomedical Sciences and Clinical & Translational Science, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA
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Received: 10 July 2018 / Revised: 27 July 2018 / Accepted: 7 August 2018 / Published: 12 August 2018
(This article belongs to the Special Issue Amino Acids Transport and Metabolism)
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Abstract

The progression of cancer is associated with increases in amino acid uptake by cancer cells. Upon their entry into cells through specific transporters, exogenous amino acids are used to synthesize proteins, nucleic acids and lipids and to generate ATP. The essential amino acid leucine is also important for maintaining cancer-associated signaling pathways. By upregulating amino acid transporters, cancer cells gain greater access to exogenous amino acids to support chronic proliferation, maintain metabolic pathways, and to enhance certain signal transduction pathways. Suppressing cancer growth by targeting amino acid transporters will require an in-depth understanding of how cancer cells acquire amino acids, in particular, the transporters involved and which cancer pathways are most sensitive to amino acid deprivation. L-Type Amino Acid Transporter 1 (LAT1) mediates the uptake of essential amino acids and its expression is upregulated during the progression of several cancers. We will review the upstream regulators of LAT1 and the downstream effects caused by the overexpression of LAT1 in cancer cells. View Full-Text
Keywords: L-Type Amino Acid Transporter 1 (LAT1); SLC7A5; mTOR; leucine; cancer L-Type Amino Acid Transporter 1 (LAT1); SLC7A5; mTOR; leucine; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Salisbury, T.B.; Arthur, S. The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer. Int. J. Mol. Sci. 2018, 19, 2373.

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