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Int. J. Mol. Sci. 2018, 19(8), 2321; https://doi.org/10.3390/ijms19082321

Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi’an 710032, China
Chong Xue and Huanyu Lu contributed equally to this paper.
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Received: 3 July 2018 / Revised: 30 July 2018 / Accepted: 6 August 2018 / Published: 8 August 2018
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Trans-ferulic acid-4-β-glucoside (C16H20O9, TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury. View Full-Text
Keywords: ferulic acid; cold acclimatization; brown adipose tissue; oxidative stress ferulic acid; cold acclimatization; brown adipose tissue; oxidative stress
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Xue, C.; Lu, H.; Liu, Y.; Zhang, J.; Wang, J.; Luo, W.; Zhang, W.; Chen, J. Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance. Int. J. Mol. Sci. 2018, 19, 2321.

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