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Int. J. Mol. Sci. 2018, 19(8), 2301; https://doi.org/10.3390/ijms19082301

Innovative Approach of Non-Thermal Plasma Application for Improving the Growth Rate in Chickens

1
Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Korea
2
Chongqing Key Laboratory of Forage and Herbivore, College of Animal Science and Technology, Southwest University, Chongqing 400715, China
3
Laboratory of Animal Genetic Engineering and Stem Cell Biology, Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju 63243, Korea
4
Department of Chemical and Biological Engineering, Jeju National University, Jeju 63243, Korea
5
Department of Animal Biotechnology, College of Animal Bioscience and Technology, Kangwon National University, Chunchon 24341, Korea
6
Department of Animal Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju 63243, Korea
7
Plasma Technology Research Center, National Fusion Research Institute, Gunsan-si, Jeollabuk-Do 54004, Korea
*
Authors to whom correspondence should be addressed.
Received: 15 June 2018 / Revised: 3 August 2018 / Accepted: 3 August 2018 / Published: 6 August 2018
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

As an innovative technology in biological applications—non-thermal plasma technique—has recently been applied to living cells and tissues. However, it is unclear whether non-thermal plasma treatment can directly regulate the growth and development of livestock. In this study, we exposed four-day-incubated fertilized eggs to plasma at 11.7 kV for 2 min, which was found to be the optimal condition in respect of highest growth rate in chickens. Interestingly, plasma-treated male chickens conspicuously grew faster than females. Plasma treatment regulated the reactive oxygen species homeostasis by controlling the mitochondrial respiratory complex activity and up-regulating the antioxidant defense system. At the same time, growth metabolism was improved due to the increase of growth hormone and insulin-like growth factor 1 and their receptors expression, and the rise of thyroid hormones and adenosine triphosphate levels through the regulation of demethylation levels of growth and hormone biosynthesis-related genes in the skeletal muscles and thyroid glands. To our knowledge, this study was the first to evaluate the effects of a non-thermal plasma treatment on the growth rate of chickens. This safe strategy might be beneficial to the livestock industry. View Full-Text
Keywords: non-thermal plasma; growth metabolism; demethylation; ATP; GH-IGF1; thyroid hormones non-thermal plasma; growth metabolism; demethylation; ATP; GH-IGF1; thyroid hormones
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, J.J.; Wang, X.Z.; Kwon, T.; Huynh, D.L.; Chandimali, N.; Kim, N.; Kang, T.Y.; Ghosh, M.; Gera, M.; Lee, S.B.; Lee, S.J.; Lee, W.S.; Kim, S.B.; Mok, Y.S.; Jeong, D.K. Innovative Approach of Non-Thermal Plasma Application for Improving the Growth Rate in Chickens. Int. J. Mol. Sci. 2018, 19, 2301.

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