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Int. J. Mol. Sci. 2018, 19(7), 1970; https://doi.org/10.3390/ijms19071970

Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases

1
School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
2
Beijing Key Lab of TCM Collateral Disease Theory Research, Capital Medical University, Beijing 100069, China
3
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
*
Author to whom correspondence should be addressed.
Received: 30 May 2018 / Revised: 28 June 2018 / Accepted: 30 June 2018 / Published: 6 July 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Neurological diseases (NDs) are a leading cause of death worldwide and tend to mainly affect people under the age of 50. High rates of premature death and disability caused by NDs undoubtedly constrain societal development. However, effective therapeutic drugs and methods are very limited. Schisandra chinensis Fructus (SCF) is the dry ripe fruit of Schisandra chinensis (Turcz.) Baill, which has been used in traditional Chinese medicine for thousands of years. Recent research has indicated that SCF and its active ingredients show a protective role in NDs, including cerebrovascular diseases, neurodegenerative diseases, or depression. The key neuroprotective mechanisms of SCF and its active ingredients have been demonstrated to include antioxidation, suppression of apoptosis, anti-inflammation, regulation of neurotransmitters, and modulation of brain-derived neurotrophic factor (BDNF) related pathways. This paper summarizes studies of the role of SCF and its active ingredients in protecting against NDs, and highlights them as promising resources for future treatment. Furthermore, novel insights on the future challenges of SCF and its active ingredients are offered. View Full-Text
Keywords: Schisandra chinensis Fructus; active ingredients; neurological diseases; molecular mechanism Schisandra chinensis Fructus; active ingredients; neurological diseases; molecular mechanism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Zhang, M.; Xu, L.; Yang, H. Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases. Int. J. Mol. Sci. 2018, 19, 1970.

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