Next Article in Journal
Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome
Previous Article in Journal
Function of the ERFL1a Transcription Factor in Wheat Responses to Water Deficiency
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2018, 19(5), 1466; https://doi.org/10.3390/ijms19051466

Cytoprotective Effect of Epigallocatechin Gallate (EGCG)-5′-O-α-Glucopyranoside, a Novel EGCG Derivative

1
Department of Integrative Biotechnology and Biomedical Institute for Convergence (BICS), Sungkyunkwan University, Suwon 16419, Korea
2
Basic Research & Innovation Division, Amorepacific Corporation R&D Center, Yongin 17074, Korea
3
Department of Biomedical Engineering, Khulna University of Engineering and Technology, Khulna 9203, Bangladesh
4
Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea
5
Department of Engineering Chemistry, Chungbuk National University, Cheongju 28644, Korea
There authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 31 March 2018 / Revised: 8 May 2018 / Accepted: 11 May 2018 / Published: 15 May 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [2987 KB, uploaded 15 May 2018]   |  

Abstract

Epigallocatechin gallate (EGCG) is a well-studied polyphenol with antioxidant effects. Since EGCG has low solubility and stability, many researchers have modified EGCG residues to ameliorate these problems. A novel EGCG derivative, EGCG-5′-O-α-glucopyranoside (EGCG-5′Glu), was synthesized, and its characteristics were investigated. EGCG-5′Glu showed antioxidant effects in cell and cell-free systems. Under SNP-derived radical exposure, EGCG-5′Glu decreased nitric oxide (NO) production, and recovered ROS-mediated cell viability. Moreover, EGCG-5′Glu regulated apoptotic pathways (caspases) and cell survival molecules (phosphoinositide 3-kinase (PI3K) and phosphoinositide-dependent kinase 1 (PDK1)). In another radical-induced condition, ultraviolet B (UVB) irradiation, EGCG-5′Glu protected cells from UVB and regulated the PI3K/PDK1/AKT pathway. Next, the proliferative effect of EGCG-5′Glu was examined. EGCG-5′Glu increased cell proliferation by modulating nuclear factor (NF)-κB activity. EGCG-5′Glu protects and repairs cells from external damage via its antioxidant effects. These results suggest that EGCG-5′Glu could be used as a cosmetics ingredient or dietary supplement. View Full-Text
Keywords: epigallocatechin gallate derivate; antioxidant; free radicals; cell survival; apoptosis epigallocatechin gallate derivate; antioxidant; free radicals; cell survival; apoptosis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Han, S.Y.; Kim, E.; Hwang, K.; Ratan, Z.A.; Hwang, H.; Kim, E.-M.; Kim, D.; Park, J.; Cho, J.Y. Cytoprotective Effect of Epigallocatechin Gallate (EGCG)-5′-O-α-Glucopyranoside, a Novel EGCG Derivative. Int. J. Mol. Sci. 2018, 19, 1466.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top