Tribute to Marcelle Grenson (1925–1996), A Pioneer in the Study of Amino Acid Transport in Yeast
Abstract
:1. First Steps at the Free University of Brussels
2. From the Role of RNAs in Protein Synthesis to Cytoplasmic Heredity
3. From Euglena to Yeast
4. From Cytoplasmic Heredity to Amino Acid Transport
5. From the “Rouge-Cloître” to the “CERIA” Research Institute
6. Methodological Improvements
7. Early Work on Amino Acid Transport: Identification of the Specific Arginine (Can1), Lysine (Lyp1), and Methionine (Mup1) Permeases
8. Exploring the Diversity of Amino Acid Permeases and First Observations on Their Regulation
8.1. Identification of a General Factor (Apf1/Shr3) Required for the Activity of Various Amino Acid Permeases
8.2. Identification of the General Amino Acid Permease (Gap1)
8.3. Identification of Other Amino Acid Permeases
8.4. Study of Uracil, Cytosine, and Uridine Uptake
8.5. Study of Ammonium Transport
8.6. Permeases as Internal-Metabolite-Retaining Systems
9. Regulation of Amino Acid Permeases
9.1. Inhibition of the Gap1 Permease by Ammonium Ions
9.2. Regulation of the Intrinsic Activity of the Ammonium Permeases
9.3. Feedback Inhibition of Permeases by Their Own Substrates and the Effect of Cycloheximide
9.4. Regulation of Permease Activity According to Cell Ploidy
10. From Classical to Molecular Genetics in Permease Studies
10.1. Installing a New Laboratory on the Campus of the Plain in Ixelles
10.2. Isolation of Mutations in the PMA1 Gene, in Collaboration with A. Goffeau
10.3. Molecular Study of the Diversity and Regulation of Amino Acid Permeases
10.4. Genetic and Molecular Study of the UGA Genes, Involved in GABA Uptake and Catabolism
11. Retirement and Last Links with the Laboratory
Acknowledgements
Conflicts of Interest
Appendix A
Appendix B
Appendix C
Appendix D
Appendix E
References
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André, B. Tribute to Marcelle Grenson (1925–1996), A Pioneer in the Study of Amino Acid Transport in Yeast. Int. J. Mol. Sci. 2018, 19, 1207. https://doi.org/10.3390/ijms19041207
André B. Tribute to Marcelle Grenson (1925–1996), A Pioneer in the Study of Amino Acid Transport in Yeast. International Journal of Molecular Sciences. 2018; 19(4):1207. https://doi.org/10.3390/ijms19041207
Chicago/Turabian StyleAndré, Bruno. 2018. "Tribute to Marcelle Grenson (1925–1996), A Pioneer in the Study of Amino Acid Transport in Yeast" International Journal of Molecular Sciences 19, no. 4: 1207. https://doi.org/10.3390/ijms19041207