MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells
AbstractMicroRNAs (miRNAs), a critical part of the RNA silencing machinery, are known to play important regulatory roles in cancer. However, the consequence of miRNA deregulation in cancer is unknown for many miRNAs. Here, we define that miRNAs, miR-17-5p, miR-132-3p/-212-3p, and miR-337-3p are significantly up-regulated in the pancreatic ductal adenocarcinomas (PDAC) compared to the normal and benign tissues. Furthermore, by using PANC-1 cells, we demonstrate that overexpressed miR-337-3p and miR-17-5p/miR-132-3p/-212-3p can regulate executioner caspases-3 and -7, respectively. In addition, over-expression of miRNAs, especially miR-337-3p, attenuates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in PANC-1 cells. Our findings unveil an important biological function for miRNAs up-regulated in PDAC in coordinately regulating caspases, potentially contributing to the malignant progression of PDAC. View Full-Text
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Park, J.K.; Doseff, A.I.; Schmittgen, T.D. MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells. Int. J. Mol. Sci. 2018, 19, 1206.
Park JK, Doseff AI, Schmittgen TD. MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells. International Journal of Molecular Sciences. 2018; 19(4):1206.Chicago/Turabian Style
Park, Jong K.; Doseff, Andrea I.; Schmittgen, Thomas D. 2018. "MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells." Int. J. Mol. Sci. 19, no. 4: 1206.
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