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Int. J. Mol. Sci. 2018, 19(3), 740; https://doi.org/10.3390/ijms19030740

Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum

1
Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH, Inhoffenstraße 7, 38124 Braunschweig, Germany
2
German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany
3
Zoological Institute, Technical University of Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany
4
Toyama Prefectural University, 5180 Kurokawa, Imizu-shi, Toyama 939-0398, Japan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 23 February 2018 / Accepted: 2 March 2018 / Published: 6 March 2018
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Basidiomycetes of the genus Hericium are among the most praised medicinal and edible mushrooms, which are known to produce secondary metabolites with the potential to treat neurodegenerative diseases. This activity has been attributed to the discovery of various terpenoids that can stimulate the production of nerve growth factor (NGF) or (as established more recently) brain-derived neurotrophic factor (BDNF) in cell-based bioassays. The present study reports on the metabolite profiles of a Lion’s Mane mushroom (Hericium erinaceus) strain and a strain of the rare species, Hericium flagellum (synonym H. alpestre). While we observed highly similar metabolite profiles between the two strains that were examined, we isolated two previously undescribed metabolites, given the trivial names erinacines Z1 and Z2. Their chemical structures were elucidated by means of nuclear magnetic resonance (NMR) spectroscopy and high resolution mass spectrometry. Along with six further, previously identified cyathane diterpenes, the novel erinacines were tested for neurotrophin inducing effects. We found that erinacines act on BDNF, which is a neurotrophic factor that has been reported recently by us to be induced by the corallocins, but as well on NGF expression, which is consistent with the literature. View Full-Text
Keywords: natural products; fungal metabolites; neurotrophic activity; fermentation; Basidiomycota natural products; fungal metabolites; neurotrophic activity; fermentation; Basidiomycota
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rupcic, Z.; Rascher, M.; Kanaki, S.; Köster, R.W.; Stadler, M.; Wittstein, K. Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum. Int. J. Mol. Sci. 2018, 19, 740.

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