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Int. J. Mol. Sci. 2018, 19(3), 650; https://doi.org/10.3390/ijms19030650

Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins?

1,2,3
,
1,2,3
,
1,2,3
,
1,2,3
and
1,2,3,*
1
University of Lille, UMR-S 1172-JPARC—Jean-Pierre Aubert Research Center, F-59000 Lille, France
2
Inserm, UMR-S 1172, Team “Mucins, Epithelial Differentiation and Carcinogenesis”, F-59000 Lille, Frances
3
CHU Lille, Service de Biochimie “Hormonologie, Métabolisme-Nutrition, Oncologie”, F-59000 Lille, France
*
Author to whom correspondence should be addressed.
Received: 21 December 2017 / Revised: 16 February 2018 / Accepted: 19 February 2018 / Published: 25 February 2018
(This article belongs to the Special Issue Targeting Cancer through RNA Biology)
Full-Text   |   PDF [2120 KB, uploaded 25 February 2018]   |  

Abstract

Functional specialization of cells and tissues in metazoans require specific gene expression patterns. Biological processes, thus, need precise temporal and spatial coordination of gene activity. Regulation of the fate of messenger RNA plays a crucial role in this context. In the present review, the current knowledge related to the role of RNA-binding proteins in the whole mRNA life-cycle is summarized. This field opens up a new angle for understanding the importance of the post-transcriptional control of gene expression in cancer cells. The emerging role of non-classic RNA-binding proteins is highlighted. The goal of this review is to encourage readers to view, through the mRNA life-cycle, novel aspects of the molecular basis of cancer and the potential to develop RNA-based therapies. View Full-Text
Keywords: mRNA life-cycle; mRNA fate; mRNA-binding proteins; mRNA-binding domains; intrinsically disordered regions; low complexity disordered regions; cytoplasmic RNA granules; DNA and RNA-binding proteins; RNA regulon; galectin-3 mRNA life-cycle; mRNA fate; mRNA-binding proteins; mRNA-binding domains; intrinsically disordered regions; low complexity disordered regions; cytoplasmic RNA granules; DNA and RNA-binding proteins; RNA regulon; galectin-3
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Coppin, L.; Leclerc, J.; Vincent, A.; Porchet, N.; Pigny, P. Messenger RNA Life-Cycle in Cancer Cells: Emerging Role of Conventional and Non-Conventional RNA-Binding Proteins? Int. J. Mol. Sci. 2018, 19, 650.

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