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Int. J. Mol. Sci. 2018, 19(2), 397; doi:10.3390/ijms19020397

Small Molecules in Rare Tumors: Emerging Role of MicroRNAs in GIST

1
Institute for Digestive Research, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50009 Kaunas, Lithuania
2
Department of Gastroenterology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu str. 2, LT-50009 Kaunas, Lithuania
Received: 16 January 2018 / Revised: 24 January 2018 / Accepted: 24 January 2018 / Published: 30 January 2018
(This article belongs to the Special Issue The Role of MicroRNAs in Human Diseases)
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Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of gastrointestinal tract. GISTs have very different clinical phenotypes and underlying molecular characteristics that are not yet completely understood. microRNAs (miRNAs) have been shown to participate in carcinogenesis pathways through post-transcriptional regulation of gene expression in different tumors. Over the last years emerging evidence has highlighted the role of miRNAs in GISTs. This review provides an overview of original research papers that analyze miRNA deregulation patterns, functional role, diagnostic, therapeutic and prognostic implications in GIST as well as provides directions for further research in the field. View Full-Text
Keywords: GIST; microRNA; isomiR; non-coding RNA; biomarker GIST; microRNA; isomiR; non-coding RNA; biomarker
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Kupcinskas, J. Small Molecules in Rare Tumors: Emerging Role of MicroRNAs in GIST. Int. J. Mol. Sci. 2018, 19, 397.

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